Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis

• Main Authors: Satoru Shindo, -, Irma Josefina Savitri, -, Takenobu Ishii, -, Atsushi Ikeda, -, Roodelyne Pierrelus, -, Alireza Heidari, -, Keisuke Okubo, -, Shin Nakamura, -, Umadevi Kandalam, -, Mohamad Rawas-Qalaji, -, Elizabeth Leon, -, Maria Rita Pastore, -, Patrick Hardigan, -, Toshihisa Kawai, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: 2022
• Subjects: RK Dentistry
• Online Access: https://repository.unair.ac.id/124765/1/6.ARTIKEL.pdf; https://repository.unair.ac.id/124765/2/6.TURNITIN.pdf; https://repository.unair.ac.id/124765/3/6.pdf; https://repository.unair.ac.id/124765/
• Institution: Universitas Airlangga

Effects of the antiosteoblastogenesis factor Semaphorin 4D (Sema4D), expressed by thrombinactivated platelets (TPs), on osteoblastogenesis, as well as osteoclastogenesis, were investigated in vitro. Intact platelets released both Sema4D and IGF-1. However, in response to stimulation with thrombin,...