Hypoxia Effects in Intervertebral Disc-Derived Stem Cells and Discus Secretomes: An in vitro Study

• Main Authors: Romaniyanto, -, Ferdiansyah Mahyudin, -, Cita Rosita Sigit Prakoeswa, -, Hari Basuki Notobroto, -, Damayanti Tinduh, -, Ryan Ausrin, -, Fedik Abdul Rantam, -, Heri Suroto, -, Dwikora Novembri Utomo, -, Sholahuddin Rhatomy, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Dove Medical Press 2022
• Subjects: R Medicine
• Online Access: https://repository.unair.ac.id/124840/1/C11_Artikel.pdf; https://repository.unair.ac.id/124840/2/C11_Turnitin.pdf; https://repository.unair.ac.id/124840/3/C11_Validasi.pdf; https://repository.unair.ac.id/124840/; https://www.dovepress.com/index.php; https://doi.org/10.2147/SCCAA.S363951
• Institution: Universitas Airlangga

Background: This study aimed to investigate the effects of hypoxia and normoxia preconditioning in rabbit intervertebral disc-derived stem cells (IVDSCs) and discus-derived conditioned medium (DD-CM)/secretomes in vitro. Transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF), fib...