Functional and Structural Impact of Deleterious Missense Single Nucleotide Polymorphisms in the NR3C1, CYP3A5, and TNF-α Genes: An In Silico Analysis

• Main Authors: Navakanth Raju Ramayanam, -, Ranjani Manickam, -, Vijayakumar Thangavel Mahalingam, -, Khang Wen Goh, -, Chrismawan Ardianto, -, Poovi Ganesan, -, Long Chiau Ming, -, Rajanandh Muhasaparur Ganesan, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2022
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125190/1/Artikel%20C-12.pdf; https://repository.unair.ac.id/125190/2/%28C-12%29%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/125190/3/Similarity%20C-12.pdf; https://repository.unair.ac.id/125190/4/Bukti%20Korespondensi%20C-12.pdf; https://repository.unair.ac.id/125190/; https://www.mdpi.com/2218-273X/12/9/1307; https://doi.org/10.3390/biom12091307
• Institution: Universitas Airlangga

Human diseases are generally influenced by SNPs (single nucleotide polymorphisms). The mutations in amino acid residues generated by deleterious SNPs contribute to the structural and functional diversity of the encoded protein. Tumor necrosis factor-α (TNF-α), Glucocorticoid receptor gene (NR3C1), a...