Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence
ABSTRACT Introduction: There is still no definitive treatment to either inhibit the degradation process or restore the damaged cartilage in osteoarthritis (OA). Various cell sources have been studied and in vitro studies showed that infrapatellar fat pad-derived mesenchymal stem cells (IFPDMSCs)...
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id-langga.1254092023-04-29T03:13:39Z https://repository.unair.ac.id/125409/ Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence Kukuh Dwiputra Hernugrahanto, Kukuh Jifaldi Afrian Maharaja Dinda Sedar, Jifaldi Djoko Santoso, Djoko Dwikora Novembri Utomo, Dwikora Dewi Masrifah Ayub, Dewi Fani Deapsari, Fani Mohammad Zaim Chilmi, Mohammad Komang Agung Irianto Suryaningrat, Komang R5-920 Medicine (General) ABSTRACT Introduction: There is still no definitive treatment to either inhibit the degradation process or restore the damaged cartilage in osteoarthritis (OA). Various cell sources have been studied and in vitro studies showed that infrapatellar fat pad-derived mesenchymal stem cells (IFPDMSCs) exhibit higher chondrogenic potential than other adipose-derived cells. Still, very few in vivo studies on IFPDMSCs for cartilage healing in OA have been reported. Aims: This systematic review will analyze the therapeutic potential of IFPDMSCs for cartilage healing in osteoarthritis from preclinical and clinical studies. Design, Methods, and Data Source: Using the PubMed, EMBASE, and Cochrane Library database up to November 30, 2020, a systematic review according to PRISMA reporting guideline was conducted on IFPDMSCs application to treat osteoarthritis in vivo studies. Inclusion criteria were in vivo preclinical and clinical studies from January 2010 to November 2020 involving the OA model or cases using IFPDMSCs to promote healing. Results: In vivo studies are scarce. Only four studies are included: two animals and two clinical studies. All included studies demonstrate favourable results of IFPDMSCs in osteoarthritis, but there is heterogeneity in outcome measurement among all studies. Conclusion: The in vitro and currently limited in vivo studies showed that infrapatellar fat pad-derived mesenchymal stem cells offer an alternative cell source with promising chondrogenic healing potential. Impact: More preclinical and clinical in vivo studies should be encouraged to explore and support the efficacy of IFPDMSCs in cell-based OA treatment to prove the promising result as those of the in vitro studies. Faculty of Medicine and Health Sciences, University Putra Malaysia Article PeerReviewed text en https://repository.unair.ac.id/125409/1/C-07%20Artikel.pdf text id https://repository.unair.ac.id/125409/2/C-07%20%20Karil.pdf text en https://repository.unair.ac.id/125409/3/C-07%20Turnitin.pdf Kukuh Dwiputra Hernugrahanto, Kukuh and Jifaldi Afrian Maharaja Dinda Sedar, Jifaldi and Djoko Santoso, Djoko and Dwikora Novembri Utomo, Dwikora and Dewi Masrifah Ayub, Dewi and Fani Deapsari, Fani and Mohammad Zaim Chilmi, Mohammad and Komang Agung Irianto Suryaningrat, Komang Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence. Malaysian Journal of Medicine and Health Sciences, 17. pp. 58-64. ISSN 1675-8544 https://medic.upm.edu.my/upload/dokumen/2021092200405310)_2021_0063.pdf |
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R5-920 Medicine (General) Kukuh Dwiputra Hernugrahanto, Kukuh Jifaldi Afrian Maharaja Dinda Sedar, Jifaldi Djoko Santoso, Djoko Dwikora Novembri Utomo, Dwikora Dewi Masrifah Ayub, Dewi Fani Deapsari, Fani Mohammad Zaim Chilmi, Mohammad Komang Agung Irianto Suryaningrat, Komang Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence |
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ABSTRACT
Introduction: There is still no definitive treatment to either inhibit the degradation process or restore the damaged
cartilage in osteoarthritis (OA). Various cell sources have been studied and in vitro studies showed that infrapatellar
fat pad-derived mesenchymal stem cells (IFPDMSCs) exhibit higher chondrogenic potential than other adipose-derived cells. Still, very few in vivo studies on IFPDMSCs for cartilage healing in OA have been reported. Aims: This
systematic review will analyze the therapeutic potential of IFPDMSCs for cartilage healing in osteoarthritis from preclinical and clinical studies. Design, Methods, and Data Source: Using the PubMed, EMBASE, and Cochrane Library
database up to November 30, 2020, a systematic review according to PRISMA reporting guideline was conducted
on IFPDMSCs application to treat osteoarthritis in vivo studies. Inclusion criteria were in vivo preclinical and clinical
studies from January 2010 to November 2020 involving the OA model or cases using IFPDMSCs to promote healing.
Results: In vivo studies are scarce. Only four studies are included: two animals and two clinical studies. All included
studies demonstrate favourable results of IFPDMSCs in osteoarthritis, but there is heterogeneity in outcome measurement among all studies. Conclusion: The in vitro and currently limited in vivo studies showed that infrapatellar fat
pad-derived mesenchymal stem cells offer an alternative cell source with promising chondrogenic healing potential.
Impact: More preclinical and clinical in vivo studies should be encouraged to explore and support the efficacy of
IFPDMSCs in cell-based OA treatment to prove the promising result as those of the in vitro studies. |
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Article PeerReviewed |
author |
Kukuh Dwiputra Hernugrahanto, Kukuh Jifaldi Afrian Maharaja Dinda Sedar, Jifaldi Djoko Santoso, Djoko Dwikora Novembri Utomo, Dwikora Dewi Masrifah Ayub, Dewi Fani Deapsari, Fani Mohammad Zaim Chilmi, Mohammad Komang Agung Irianto Suryaningrat, Komang |
author_facet |
Kukuh Dwiputra Hernugrahanto, Kukuh Jifaldi Afrian Maharaja Dinda Sedar, Jifaldi Djoko Santoso, Djoko Dwikora Novembri Utomo, Dwikora Dewi Masrifah Ayub, Dewi Fani Deapsari, Fani Mohammad Zaim Chilmi, Mohammad Komang Agung Irianto Suryaningrat, Komang |
author_sort |
Kukuh Dwiputra Hernugrahanto, Kukuh |
title |
Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence |
title_short |
Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence |
title_full |
Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence |
title_fullStr |
Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence |
title_full_unstemmed |
Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells as an Alternative Cell Source for Cell-based Osteoarthritis Treatment: A Systematic Review on Preclinical and Clinical Evidence |
title_sort |
infrapatellar fat pad-derived mesenchymal stem cells as an alternative cell source for cell-based osteoarthritis treatment: a systematic review on preclinical and clinical evidence |
publisher |
Faculty of Medicine and Health Sciences, University Putra Malaysia |
url |
https://repository.unair.ac.id/125409/1/C-07%20Artikel.pdf https://repository.unair.ac.id/125409/2/C-07%20%20Karil.pdf https://repository.unair.ac.id/125409/3/C-07%20Turnitin.pdf https://repository.unair.ac.id/125409/ https://medic.upm.edu.my/upload/dokumen/2021092200405310)_2021_0063.pdf |
_version_ |
1765216183274962944 |