In silico estrogen receptor alpha antagonist studies and toxicity prediction of Melia azedarach leaves bioactive ethyl acetate fraction

• Main Authors: Martha Ervina, -, Mohammad Rizki Fadhil Pratama, -, Hadi Poerwono, -, Juni Ekowati, -, Retno Widyowati, -, Katsuyoshi Matsunami, -, Sukardiman, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Wolter Kluwers Health 2021
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125480/1/C-20_artikel.pdf; https://repository.unair.ac.id/125480/2/Kualitas%20Karil%20C-20.pdf; https://repository.unair.ac.id/125480/3/C-20_similarity.pdf; https://repository.unair.ac.id/125480/; https://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=3;spage=236;epage=241;aulast=Ervina
• Institution: Universitas Airlangga

The estrogen hormone dependent accounts for a major cause in the incidence of women breast cancer. Thus, their receptor, especially the estrogen receptor α (ER-α), is becoming a target in endocrine treatment. These ligand-inducible nuclear functions are regulated by an array of phytochemical and syn...