Mucormycosis in Indian COVID-19 patients: insight into its patho-genesis, clinical manifestation, and management strategies

• Main Authors: Ram Kumar Sahu, -, Mounir M Salem-Bekhit, -, Bedanta Bhattacharjee, -, Yosif Almoshari, -, Abu Md Ashif Ikbal, -, Meshal Alshamrani, -, Alakesh Bharali, -, Ahmad Salawi, -, Retno Widyowati, -, Abdulrahman Alshammari, -, Ibrahim Elbagory, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2023
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125497/1/C-25_artikel.pdf; https://repository.unair.ac.id/125497/2/Kualitas%20Karil%20C-25.pdf; https://repository.unair.ac.id/125497/3/C-25_similarity.pdf; https://repository.unair.ac.id/125497/; https://www.mdpi.com/2079-6382/10/9/1079; https://doi.org/10.3390/antibiotics10091079
• Institution: Universitas Airlangga

Mucormycosis in patients who have COVID-19 or who are otherwise immunocompromised has become a global problem, causing significant morbidity and mortality. Infection is debilitating and fatal, leading to loss of organs and emotional trauma. Radiographic manifestations are not specific, but diagnosis can be made through microscopic examination of materials collected from necrotic lesions. Treatment requires multidisciplinary expertise, as the fungus enters through the eyes and nose and may even reach the brain. Use of the many antifungal drugs available is limited by considerations of resistance and toxicity, but nanoparticles can overcome such limitations by reducing toxicity and increasing bioavailability. The lipid formulation of amphotericin-B (liposomal Am-B) is the first-line treatment for mucormycosis in COVID-19 patients, but its high cost and low availability have prompted a shift toward surgery, so that surgical debridement to remove all necrotic lesions remains the hallmark of effective treatment of mucormycosis in COVID-19. This review highlights the pathogenesis, clinical manifestation, and management of mucormycosis in patients who have COVID-19.