Nanotechnology integration for sars-cov-2 diagnosis and treatment: An approach to preventing pandemic

• Main Authors: Syed Mohammed Basheeruddin Asdaq, -, Abu Md Ashif Ikbal, -, Ram Kumar Sahu, -, Bedanta Bhattacharjee, -, Tirna Paul, -, Bhargab Deka, -, Santosh Fattepur, -, Retno Widyowati, -, Joshi Vijaya, -, Mohammed Al mohaini, -, Abdulkhaliq J Alsalman, -, Mohd Imran, -, Sreeharsha Nagaraja, -, Anroop B. Nair, -, Mahesh Attimarad, -, Katharigatta N. Venugopala, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2021
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125498/1/Artikel%20C-26.pdf; https://repository.unair.ac.id/125498/2/Kualitas%20Karil%20C-26.pdf; https://repository.unair.ac.id/125498/3/C-26_artikel_similarity.pdf; https://repository.unair.ac.id/125498/; https://www.mdpi.com/2079-4991/11/7/1841; https://doi.org/10.3390/nano11071841
• Institution: Universitas Airlangga

The SARS-CoV-2 outbreak is the COVID-19 disease, which has caused massive health devastation, prompting the World Health Organization to declare a worldwide health emergency. The corona virus infected millions of people worldwide, and many died as a result of a lack of particular medications. The current emergency necessitates extensive therapy in order to stop the spread of the coronavirus. There are various vaccinations available, but no validated COVID-19 treatments. Since its outbreak, many therapeutics have been tested, including the use of repurposed medications, nucleoside inhibitors, protease inhibitors, broad spectrum antivirals, convalescence plasma therapies, immune-modulators, and monoclonal antibodies. However, these approaches have not yielded any outcomes and are mostly used to alleviate symptoms associated with potentially fatal adverse drug reactions. Nanoparticles, on the other hand, may prove to be an effective treatment for COVID-19. They can be designed to boost the efficacy of currently available antiviral medications or to trigger a rapid immune response against COVID-19. In the last decade, there has been significant progress in nanotechnology. This review focuses on the virus’s basic structure, pathogenesis, and current treatment options for COVID-19. This study addresses nanotechnology and its applications in diagnosis, prevention, treatment, and targeted vaccine delivery, laying the groundwork for a successful pandemic fight.