Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia

Background: Chronic dyspepsia's symptoms are frequently seen in primary to tertiary healthcare in Indonesia. This study aimed to describe the potential usability of pepsinogen (PG) values in determining gastric mucosal conditions, including superficial gastritis and atrophic gastritis. Mate...

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Main Authors: Muhammad Miftahussurur, Langgeng Agung Waskito, Ari Fahrial Syam, Iswan Abbas Nusi, I Dewa Nyoman Wibawa, Yudith Annisa Ayu Rezkitha, Kartika Afrida Fauzia, Gontar Alamsyah Siregar, Fardah Akil, Bradley Jimmy Waleleng, Alexander Michael Joseph Saudale, Azzaki Abubakar, Hasan Maulahela, Maselino Richardo, Abdul Rahman, Yoma Sari Namaro, Eko Sudarmo, Pangestu Adi, Ummi Maimunah, Poernomo Boedi Setiawan, Dalla Doohan, Tomohisa Uchida, Astri Dewayani, Purwo Sri Rejeki, Titong Sugihartono, Yoshio Yamaoka
Format: Article PeerReviewed
Language:English
English
English
Published: Wolters Kluwer Medknow Publications 2022
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Online Access:https://repository.unair.ac.id/125582/1/16.Serum_pepsinogen_level.pdf
https://repository.unair.ac.id/125582/2/16.Karil_Serum_pepsinogen_level.pdf
https://repository.unair.ac.id/125582/3/16.Similarity_Serum_pepsinogen_level.pdf
https://repository.unair.ac.id/125582/
https://www.jmsjournal.net/downloadpdf.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=90;epage=90;aulast=Miftahussurur;type=2
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spelling id-langga.1255822023-04-28T15:52:03Z https://repository.unair.ac.id/125582/ Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia Muhammad Miftahussurur Langgeng Agung Waskito Ari Fahrial Syam Iswan Abbas Nusi I Dewa Nyoman Wibawa Yudith Annisa Ayu Rezkitha Kartika Afrida Fauzia Gontar Alamsyah Siregar Fardah Akil Bradley Jimmy Waleleng Alexander Michael Joseph Saudale Azzaki Abubakar Hasan Maulahela Maselino Richardo Abdul Rahman Yoma Sari Namaro Eko Sudarmo Pangestu Adi Ummi Maimunah Poernomo Boedi Setiawan Dalla Doohan Tomohisa Uchida Astri Dewayani Purwo Sri Rejeki Titong Sugihartono Yoshio Yamaoka RC31-1245 Internal medicine Background: Chronic dyspepsia's symptoms are frequently seen in primary to tertiary healthcare in Indonesia. This study aimed to describe the potential usability of pepsinogen (PG) values in determining gastric mucosal conditions, including superficial gastritis and atrophic gastritis. Materials and Methods: We recruited 646 adult dyspeptic patients and then analyzed PG values (including PGI, PGII, and PGI/II ratio) with endoscopic findings, gastric mucosal damages, and Helicobacter pylori infection. The gastric mucosal damage and H. pylori infection were evaluated using histological examination based on the updated Sydney system. Results: Among 646 enrolled patients, 308 (47.2%), 212 (32.8%), 91 (14.1%), 34 (5.2%), and 1 (0.2%) patient were diagnosed with normal mucosa, gastritis, reflux esophagitis, peptic ulcer disease, and gastric cancer, respectively. Significant differences in PGI, PGII, and PGI/II ratio values were observed among ethnic groups (all P < 0.01). The PGI and PGII levels were significantly higher and PGI/II was significantly lower in H. pylori-infected patients than in uninfected ones (all P < 0.001). The optimal cutoff value for PGII and PGI/II was 12.45 ng/mL with an area under the curve (AUC) value of 0.755 (0.702–0.811), sensitivity 59.3%, and specificity 77.1%; and 4.75 with AUC value of 0.821 (0.763–0.855), sensitivity 81.5%, and specificity 78.7%, respectively, to determine moderate–severe atrophy. Conclusion: Serum PG levels, a useful biomarker, represent the endoscopic findings, especially for reflux esophagitis. In addition, the benefits of PG values detecting atrophic gastritis were limited to moderate–severe atrophic gastritis. This usefulness requires careful attention for several ethnic groups in Indonesia. Wolters Kluwer Medknow Publications 2022 Article PeerReviewed text en https://repository.unair.ac.id/125582/1/16.Serum_pepsinogen_level.pdf text en https://repository.unair.ac.id/125582/2/16.Karil_Serum_pepsinogen_level.pdf text en https://repository.unair.ac.id/125582/3/16.Similarity_Serum_pepsinogen_level.pdf Muhammad Miftahussurur and Langgeng Agung Waskito and Ari Fahrial Syam and Iswan Abbas Nusi and I Dewa Nyoman Wibawa and Yudith Annisa Ayu Rezkitha and Kartika Afrida Fauzia and Gontar Alamsyah Siregar and Fardah Akil and Bradley Jimmy Waleleng and Alexander Michael Joseph Saudale and Azzaki Abubakar and Hasan Maulahela and Maselino Richardo and Abdul Rahman and Yoma Sari Namaro and Eko Sudarmo and Pangestu Adi and Ummi Maimunah and Poernomo Boedi Setiawan and Dalla Doohan and Tomohisa Uchida and Astri Dewayani and Purwo Sri Rejeki and Titong Sugihartono and Yoshio Yamaoka (2022) Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia. Journal of Research in Medical Sciences. ISSN 1735-7136 https://www.jmsjournal.net/downloadpdf.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=90;epage=90;aulast=Miftahussurur;type=2
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
English
topic RC31-1245 Internal medicine
spellingShingle RC31-1245 Internal medicine
Muhammad Miftahussurur
Langgeng Agung Waskito
Ari Fahrial Syam
Iswan Abbas Nusi
I Dewa Nyoman Wibawa
Yudith Annisa Ayu Rezkitha
Kartika Afrida Fauzia
Gontar Alamsyah Siregar
Fardah Akil
Bradley Jimmy Waleleng
Alexander Michael Joseph Saudale
Azzaki Abubakar
Hasan Maulahela
Maselino Richardo
Abdul Rahman
Yoma Sari Namaro
Eko Sudarmo
Pangestu Adi
Ummi Maimunah
Poernomo Boedi Setiawan
Dalla Doohan
Tomohisa Uchida
Astri Dewayani
Purwo Sri Rejeki
Titong Sugihartono
Yoshio Yamaoka
Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
description Background: Chronic dyspepsia's symptoms are frequently seen in primary to tertiary healthcare in Indonesia. This study aimed to describe the potential usability of pepsinogen (PG) values in determining gastric mucosal conditions, including superficial gastritis and atrophic gastritis. Materials and Methods: We recruited 646 adult dyspeptic patients and then analyzed PG values (including PGI, PGII, and PGI/II ratio) with endoscopic findings, gastric mucosal damages, and Helicobacter pylori infection. The gastric mucosal damage and H. pylori infection were evaluated using histological examination based on the updated Sydney system. Results: Among 646 enrolled patients, 308 (47.2%), 212 (32.8%), 91 (14.1%), 34 (5.2%), and 1 (0.2%) patient were diagnosed with normal mucosa, gastritis, reflux esophagitis, peptic ulcer disease, and gastric cancer, respectively. Significant differences in PGI, PGII, and PGI/II ratio values were observed among ethnic groups (all P < 0.01). The PGI and PGII levels were significantly higher and PGI/II was significantly lower in H. pylori-infected patients than in uninfected ones (all P < 0.001). The optimal cutoff value for PGII and PGI/II was 12.45 ng/mL with an area under the curve (AUC) value of 0.755 (0.702–0.811), sensitivity 59.3%, and specificity 77.1%; and 4.75 with AUC value of 0.821 (0.763–0.855), sensitivity 81.5%, and specificity 78.7%, respectively, to determine moderate–severe atrophy. Conclusion: Serum PG levels, a useful biomarker, represent the endoscopic findings, especially for reflux esophagitis. In addition, the benefits of PG values detecting atrophic gastritis were limited to moderate–severe atrophic gastritis. This usefulness requires careful attention for several ethnic groups in Indonesia.
format Article
PeerReviewed
author Muhammad Miftahussurur
Langgeng Agung Waskito
Ari Fahrial Syam
Iswan Abbas Nusi
I Dewa Nyoman Wibawa
Yudith Annisa Ayu Rezkitha
Kartika Afrida Fauzia
Gontar Alamsyah Siregar
Fardah Akil
Bradley Jimmy Waleleng
Alexander Michael Joseph Saudale
Azzaki Abubakar
Hasan Maulahela
Maselino Richardo
Abdul Rahman
Yoma Sari Namaro
Eko Sudarmo
Pangestu Adi
Ummi Maimunah
Poernomo Boedi Setiawan
Dalla Doohan
Tomohisa Uchida
Astri Dewayani
Purwo Sri Rejeki
Titong Sugihartono
Yoshio Yamaoka
author_facet Muhammad Miftahussurur
Langgeng Agung Waskito
Ari Fahrial Syam
Iswan Abbas Nusi
I Dewa Nyoman Wibawa
Yudith Annisa Ayu Rezkitha
Kartika Afrida Fauzia
Gontar Alamsyah Siregar
Fardah Akil
Bradley Jimmy Waleleng
Alexander Michael Joseph Saudale
Azzaki Abubakar
Hasan Maulahela
Maselino Richardo
Abdul Rahman
Yoma Sari Namaro
Eko Sudarmo
Pangestu Adi
Ummi Maimunah
Poernomo Boedi Setiawan
Dalla Doohan
Tomohisa Uchida
Astri Dewayani
Purwo Sri Rejeki
Titong Sugihartono
Yoshio Yamaoka
author_sort Muhammad Miftahussurur
title Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
title_short Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
title_full Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
title_fullStr Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
title_full_unstemmed Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
title_sort serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in indonesia
publisher Wolters Kluwer Medknow Publications
publishDate 2022
url https://repository.unair.ac.id/125582/1/16.Serum_pepsinogen_level.pdf
https://repository.unair.ac.id/125582/2/16.Karil_Serum_pepsinogen_level.pdf
https://repository.unair.ac.id/125582/3/16.Similarity_Serum_pepsinogen_level.pdf
https://repository.unair.ac.id/125582/
https://www.jmsjournal.net/downloadpdf.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=90;epage=90;aulast=Miftahussurur;type=2
_version_ 1765216210932203520