Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study

Previous studies have yielded inconsistent results on whether glycated hemoglobin (HbA1c) and random blood glucose (RBG) are associated with mortality of coronavirus disease 2019 (COVID-19) patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the association of HbA1c and RBG wit...

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Main Authors: Stefanus Gunawan Kanindita, -, Soebagijo Adi Soelistijo, -, Agung Pranoto, -, Erwin Astha Triyono, -
Format: Article PeerReviewed
Language:English
English
English
English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2023
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Online Access:https://repository.unair.ac.id/125749/1/15.pdf
https://repository.unair.ac.id/125749/2/Artikel%2015.pdf
https://repository.unair.ac.id/125749/3/Similarity%2015.pdf
https://repository.unair.ac.id/125749/4/Bukti%20Korespondensi%2015.pdf
https://repository.unair.ac.id/125749/
https://www.mdpi.com/1873-149X/30/2/12
https://doi.org/10.3390/pathophysiology30020012
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spelling id-langga.1257492023-04-29T05:40:04Z https://repository.unair.ac.id/125749/ Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study Stefanus Gunawan Kanindita, - Soebagijo Adi Soelistijo, - Agung Pranoto, - Erwin Astha Triyono, - R Medicine (General) RC Internal medicine Previous studies have yielded inconsistent results on whether glycated hemoglobin (HbA1c) and random blood glucose (RBG) are associated with mortality of coronavirus disease 2019 (COVID-19) patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the association of HbA1c and RBG with mortality among COVID-19 patients with T2DM. A retrospective study was conducted on 237 patients with COVID-19 and T2DM (survival (n = 169) and non-survival groups (n = 68)). Data on socio-demography, comorbidities, clinical symptoms, laboratory examination, and mortality were collected. Patients in the non-survival group had an older age range as compared with those in the survival group (60 (52.3–65.0) vs. 56.0 (48.5–61.5) years, p = 0.009). There was no statistical gender difference between the two groups. After matching was done, chronic kidney disease, NLR, d-dimer, procalcitonin, and random blood glucose were higher in the non-survival group compared to the survival group (p < 0.05). HbA1c levels were similar in survivors and non-survivors (8.7% vs. 8.9%, p=0.549). The level of RBG was independently associated with mortality of COVID-19 patients with T2DM (p = 0.003, adjusted OR per 1-SD increment 2.55, 95% CI: 1.36–4.76). In conclusion, RBG was associated with the mortality of COVID-19 patients with T2DM, but HbA1c was not. Multidisciplinary Digital Publishing Institute (MDPI) 2023 Article PeerReviewed text en https://repository.unair.ac.id/125749/1/15.pdf text en https://repository.unair.ac.id/125749/2/Artikel%2015.pdf text en https://repository.unair.ac.id/125749/3/Similarity%2015.pdf text en https://repository.unair.ac.id/125749/4/Bukti%20Korespondensi%2015.pdf Stefanus Gunawan Kanindita, - and Soebagijo Adi Soelistijo, - and Agung Pranoto, - and Erwin Astha Triyono, - (2023) Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study. Pathophysiology, 30 (2). pp. 136-143. ISSN 0928-4680 https://www.mdpi.com/1873-149X/30/2/12 https://doi.org/10.3390/pathophysiology30020012
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
English
English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Stefanus Gunawan Kanindita, -
Soebagijo Adi Soelistijo, -
Agung Pranoto, -
Erwin Astha Triyono, -
Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study
description Previous studies have yielded inconsistent results on whether glycated hemoglobin (HbA1c) and random blood glucose (RBG) are associated with mortality of coronavirus disease 2019 (COVID-19) patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the association of HbA1c and RBG with mortality among COVID-19 patients with T2DM. A retrospective study was conducted on 237 patients with COVID-19 and T2DM (survival (n = 169) and non-survival groups (n = 68)). Data on socio-demography, comorbidities, clinical symptoms, laboratory examination, and mortality were collected. Patients in the non-survival group had an older age range as compared with those in the survival group (60 (52.3–65.0) vs. 56.0 (48.5–61.5) years, p = 0.009). There was no statistical gender difference between the two groups. After matching was done, chronic kidney disease, NLR, d-dimer, procalcitonin, and random blood glucose were higher in the non-survival group compared to the survival group (p < 0.05). HbA1c levels were similar in survivors and non-survivors (8.7% vs. 8.9%, p=0.549). The level of RBG was independently associated with mortality of COVID-19 patients with T2DM (p = 0.003, adjusted OR per 1-SD increment 2.55, 95% CI: 1.36–4.76). In conclusion, RBG was associated with the mortality of COVID-19 patients with T2DM, but HbA1c was not.
format Article
PeerReviewed
author Stefanus Gunawan Kanindita, -
Soebagijo Adi Soelistijo, -
Agung Pranoto, -
Erwin Astha Triyono, -
author_facet Stefanus Gunawan Kanindita, -
Soebagijo Adi Soelistijo, -
Agung Pranoto, -
Erwin Astha Triyono, -
author_sort Stefanus Gunawan Kanindita, -
title Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study
title_short Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study
title_full Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study
title_fullStr Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study
title_full_unstemmed Random Blood Glucose, but Not HbA1c, Was Associated with Mortality in COVID-19 Patients with Type 2 Diabetes Mellitus—A Retrospective Study
title_sort random blood glucose, but not hba1c, was associated with mortality in covid-19 patients with type 2 diabetes mellitus—a retrospective study
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2023
url https://repository.unair.ac.id/125749/1/15.pdf
https://repository.unair.ac.id/125749/2/Artikel%2015.pdf
https://repository.unair.ac.id/125749/3/Similarity%2015.pdf
https://repository.unair.ac.id/125749/4/Bukti%20Korespondensi%2015.pdf
https://repository.unair.ac.id/125749/
https://www.mdpi.com/1873-149X/30/2/12
https://doi.org/10.3390/pathophysiology30020012
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