The role of vitamin d deficiency towards cognitive deficit of schizophrenia

• Main Authors: Azimatul Karimah, Kristanti Sulistyo Rahayu, Aryati
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Foundation for Enviromentak Protection and Research 2020
• Subjects: R Medicine (General); RZ Other systems of medicine
• Online Access: https://repository.unair.ac.id/125810/1/9.pdf; https://repository.unair.ac.id/125810/2/9.pdf; https://repository.unair.ac.id/125810/3/9.pdf; https://repository.unair.ac.id/125810/; https://scholar.unair.ac.id/en/publications/the-role-of-vitamin-d-deficiency-towards-cognitive-deficit-of-sch
• Institution: Universitas Airlangga

Background: Vitamin D receptor (VDR) discovery in the brain tissue demonstrates clearly that vitamin D has a significant role in the development of the brain. This study aimed to analyze the correlation between serum vitamin D levels and cognitive deficits in schizophrenic patients. Methods: This was an observational analytic study with cross-sectional design. Serum vitamin D levels were measured using VIDAS® 25 OH Vitamin D Total (VITD). Cognitive deficits were measured using Indonesian version of the Schizophrenia Cognition Rating Scale (ScoRSvI). Results: This study recruited 54 patients from outpatient and inpatient unit of psychiatric. Most of subjects were male as many as 25 (65.8%). Mean age of subjects was 34.84 years. Mean duration of illness was 10.58±7.4 years. There were 17 (45%) subjects experienced serum vitamin D deficiency, and 22 (58%) study subjects had cognitive deficits on the global impression of ScoRSvI assessment by rater. There was a significant negative correlation (p <0.001) between serum vitamin D levels and SCoRSvI values from the impression of global observations, ScoRSvI patients, and ScoRSvI informants. Conclusion: The lower serum vitamin D levels, the higher score of cognitive deficits from SCoRSvI. The higher SCoRSvI score shows the more severe cognitive deficit for patients with schizophrenia.