Carbon paste electrode modified molecularly imprinted polymer as a sensor for creatinine analysis by stripping voltammetry

• Main Authors: Miratul Khasanah, H. Darmokoesoemo, D. A. Rizki
• Format: Book Section PeerReviewed
• Language: English; English; English; English
• Published: AIP Publishing 2017
• Subjects: Q Science; QD Chemistry; QD71-142 Analytical chemistry
• Online Access: https://repository.unair.ac.id/125999/1/C28.%20Fulltext.pdf; https://repository.unair.ac.id/125999/2/C28.%20Penilaian%20dan%20Validasi.pdf; https://repository.unair.ac.id/125999/3/C28.%20Similarity.pdf; https://repository.unair.ac.id/125999/7/C28.%20Bukti%20Korespondensi.pdf; https://repository.unair.ac.id/125999/; https://pubs.aip.org/aip/acp/article/1888/1/020033/767794/Carbon-paste-electrode-modified-molecularly
• Institution: Universitas Airlangga

Modification of carbon paste electrode with molecularly imprinted polymer (CP-MIP) as a voltammetric sensor for creatinine has been developed. MIP was synthesized by reacting melamine, chloranil and creatinine with a mole ratio of 1:1:0.1. Creatinine was extracted from polymer chain by using hot water to form a specific imprinted for creatinine molecule. Carbon paste-MIP electrode was prepared by mixing activated carbon, solid paraffin, and MIP in a 45:40:15(w/w %) ratio. The optimum conditions of creatinine analysis by differential pulse stripping voltammetry (DPSV) using the developed electrode were the accumulation potential -1000 mV during 90 s at pH 5. The precision of the method for 0.1-0.5 μlg/L creatinine was 88.7–96.3%, while the detection limit of this method was 0.0315 μlg/L. The accuracy compared by spectrophotometric method was 95.3–103.6%