25(OH)D Inadequacy Has Different Pathway with VEGF in Increases the Risk of Severe Preeclampsia

• Main Authors: Hanifa Erlin Damayanti, -, Aditiawarman, -
• Format: Article PeerReviewed
• Language: English; English; English; English; Indonesian
• Published: Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia 2015
• Subjects: R Medicine (General); RG Gynecology and obstetrics
• Online Access: https://repository.unair.ac.id/126155/1/Artikel%2029.pdf; https://repository.unair.ac.id/126155/2/Karil%2029.pdf; https://repository.unair.ac.id/126155/3/Similarity%2029.pdf; https://repository.unair.ac.id/126155/7/31.%2025%28OH%29D%20Inadequacy%20Has%20Different%20Pathway%20with%20VEGF.pdf; https://repository.unair.ac.id/126155/8/31.%2025%28OH%29D%20Inadequacy%20Has%20Different%20Pathway.pdf; https://repository.unair.ac.id/126155/; https://e-journal.unair.ac.id/MOG/article/view/2088; https://doi.org/10.20473/mog.V23I22015.42-48
• Institution: Universitas Airlangga

Objectives: To identify in vivo correlation between 25(OH)D and VEGF in severe preeclampsia. Materials and Methods: A case control, cross sectional study of 36 pregnant women which consist of 18 patients with preeclampsia and 18 patients as control with gestational age-matched. We perform 25(OH)D serum examination by chemiluminescent immunoassay (CLIA) and VEGF serum examination by sandwich ELISA to all patients. Results: All patients are in 25(OH)D insufficiency and deficiency state. Both maternal 25(OH)D and VEGF levels were inversely associated with the risk of preeclampsia (both P<0.05). There is no correlation between 25(OH)D serum level and VEGF serum level (P=0,629). Conclusion: Maternal vitamin D deficiency is associated with increased preeclampsia risk. However, our data do not support the hypothesis that the association between vitamin D deficiency and preeclampsia is mediated by impaired level of VEGF.