Comparison of serum soluble edoglin (sEng) level in eary onset preeclampsia, late onset preeclampsia and normal pregnant woman
Objectives: This study aimed to compare the serum levels of soluble Endoglin (s-Eng) between early onset preeclampsia, late onset preeclampsia and normal pregnant women. Materials and Methods: This was an analytic observational study (Cross-Sectional) performed on 39 pregnant women with early-onset...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English English English |
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Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2017
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| Online Access: | https://repository.unair.ac.id/126164/1/Similarity%2031.pdf https://repository.unair.ac.id/126164/2/Karil%2031.pdf https://repository.unair.ac.id/126164/3/Artikel%2031.pdf https://repository.unair.ac.id/126164/6/33.%20COMPARISON%20OF%20SERUM%20SOLUBLE%20EDOGLIN%20%28SENG%29%20LEVEL.pdf https://repository.unair.ac.id/126164/ https://e-journal.unair.ac.id/MOG/article/view/7953 https://doi.org/10.20473/mog.V25I12017.10-15 |
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| Institution: | Universitas Airlangga |
| Language: | English English English English |
| Summary: | Objectives: This study aimed to compare the serum levels of soluble Endoglin (s-Eng) between early onset preeclampsia, late onset preeclampsia and normal pregnant women. Materials and Methods: This was an analytic observational study (Cross-Sectional) performed on 39 pregnant women with early-onset preeclampsia (EO-PE), late-onset preeclampsia (LO-PE), and normal pregnancy. The patients were consecutively chosen in Dr. Soetomo Hospital, Airlangga University Hospital and Dr. M. Soewandhi Hospital Surabaya in May-July 2016. The serum concentration of soluble Endoglin were collected by venous puncture taken from maternal circulation and measured by ELISA. Results: From this study, serum concentrations of soluble Endoglin was higher significantly on the early onset preeclampsia compared with late onset preeclampsia and normal pregnancy (47,65 ± 40,17 vs 13,46 ± 9,48 vs 6,11 ± 1,45 ng/mL; p=0.000). Conclusion: This study shows angiogenic imbalance was more prominent compared in early-onset than late-onset preeclampsia. This may be because the placental dysfunction, placental ischemia, which produce excessive anti angiogenic factors, whic later causing endothelial dysfunction was more related to early onset preeclampsia. |
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