Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury

Abstract Introduction The central nervous system (CNS) is the most metabolically active organ characterized by high oxygen demand and relatively low anti-oxidative activity, which makes neurons and glia highly susceptible to damage by reactive oxygen and nitrogen byproducts as well as neurodegener...

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Main Authors: Rizha Anshori Nasution, -, Andi Asadul Islam, Andi, Mochammad Hatta, Mochammad, Prihantono, -, Agus Turchan, Agus, Nasrullah, -, Muhammad Faruk, Muhammad
Format: Article PeerReviewed
Language:English
Indonesian
English
Published: Elsevier
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Online Access:https://repository.unair.ac.id/126190/1/19%20artikel.pdf
https://repository.unair.ac.id/126190/2/19A_Karil.pdf
https://repository.unair.ac.id/126190/3/19%20Turnitin.pdf
https://repository.unair.ac.id/126190/
https://www.sciencedirect.com/science/article/pii/S2049080120302181
https://doi.org/10.1016/j.amsu.2020.07.036
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spelling id-langga.1261902023-05-05T02:04:07Z https://repository.unair.ac.id/126190/ Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury Rizha Anshori Nasution, - Andi Asadul Islam, Andi Mochammad Hatta, Mochammad Prihantono, - Agus Turchan, Agus Nasrullah, - Muhammad Faruk, Muhammad R Medicine R5-920 Medicine (General) Abstract Introduction The central nervous system (CNS) is the most metabolically active organ characterized by high oxygen demand and relatively low anti-oxidative activity, which makes neurons and glia highly susceptible to damage by reactive oxygen and nitrogen byproducts as well as neurodegeneration. Free radicals are associated with secondary injuries that occur after a primary brain injury. Some of these free radical products include F2-Isoprostane (F2-IsoPs), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) and acrolein. Methods In this study we measured serum F2-IsoPs levels as markers of free radical activity in 10–12 week-old male Sprague-Dawley rats weighing 200–300 g, all rats (n = 10) subjected with a head injury according to the modified marmourou model, then divided into 2 groups, one group treated with CAPE (Caffeic Acid Phenethyl Ester) (n = 5) and the other not treated with CAPE (n = 5), serum levels in the two groups were compared starting from day-0 (before brain injury), day-4 and day-7. Results We found lower F2-IsoPs levels in the group that received the CAPE treatment compared to the group that did not receive the CAPE treatment. Conclusion CAPE is capable of significantly reducing oxidative stress in brain injury. Elsevier Article PeerReviewed text en https://repository.unair.ac.id/126190/1/19%20artikel.pdf text id https://repository.unair.ac.id/126190/2/19A_Karil.pdf text en https://repository.unair.ac.id/126190/3/19%20Turnitin.pdf Rizha Anshori Nasution, - and Andi Asadul Islam, Andi and Mochammad Hatta, Mochammad and Prihantono, - and Agus Turchan, Agus and Nasrullah, - and Muhammad Faruk, Muhammad Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury. Annals of Medicine and Surgery, 57. pp. 118-122. ISSN '2049-0801 https://www.sciencedirect.com/science/article/pii/S2049080120302181 https://doi.org/10.1016/j.amsu.2020.07.036
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
Indonesian
English
topic R Medicine
R5-920 Medicine (General)
spellingShingle R Medicine
R5-920 Medicine (General)
Rizha Anshori Nasution, -
Andi Asadul Islam, Andi
Mochammad Hatta, Mochammad
Prihantono, -
Agus Turchan, Agus
Nasrullah, -
Muhammad Faruk, Muhammad
Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury
description Abstract Introduction The central nervous system (CNS) is the most metabolically active organ characterized by high oxygen demand and relatively low anti-oxidative activity, which makes neurons and glia highly susceptible to damage by reactive oxygen and nitrogen byproducts as well as neurodegeneration. Free radicals are associated with secondary injuries that occur after a primary brain injury. Some of these free radical products include F2-Isoprostane (F2-IsoPs), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) and acrolein. Methods In this study we measured serum F2-IsoPs levels as markers of free radical activity in 10–12 week-old male Sprague-Dawley rats weighing 200–300 g, all rats (n = 10) subjected with a head injury according to the modified marmourou model, then divided into 2 groups, one group treated with CAPE (Caffeic Acid Phenethyl Ester) (n = 5) and the other not treated with CAPE (n = 5), serum levels in the two groups were compared starting from day-0 (before brain injury), day-4 and day-7. Results We found lower F2-IsoPs levels in the group that received the CAPE treatment compared to the group that did not receive the CAPE treatment. Conclusion CAPE is capable of significantly reducing oxidative stress in brain injury.
format Article
PeerReviewed
author Rizha Anshori Nasution, -
Andi Asadul Islam, Andi
Mochammad Hatta, Mochammad
Prihantono, -
Agus Turchan, Agus
Nasrullah, -
Muhammad Faruk, Muhammad
author_facet Rizha Anshori Nasution, -
Andi Asadul Islam, Andi
Mochammad Hatta, Mochammad
Prihantono, -
Agus Turchan, Agus
Nasrullah, -
Muhammad Faruk, Muhammad
author_sort Rizha Anshori Nasution, -
title Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury
title_short Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury
title_full Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury
title_fullStr Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury
title_full_unstemmed Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury
title_sort role of cape in reducing oxidative stress in animal models with traumatic brain injury
publisher Elsevier
url https://repository.unair.ac.id/126190/1/19%20artikel.pdf
https://repository.unair.ac.id/126190/2/19A_Karil.pdf
https://repository.unair.ac.id/126190/3/19%20Turnitin.pdf
https://repository.unair.ac.id/126190/
https://www.sciencedirect.com/science/article/pii/S2049080120302181
https://doi.org/10.1016/j.amsu.2020.07.036
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