Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.

Abstract Background: Neonatal sepsis is a problem of morbidity and mortality that still occurs in neonates. This neonatal sepsis can cause 1/4 of the total deaths in neonates in the world. The incidence can increase to 13-27 cases per 1000 live births in babies born weighing <1500 grams. Objecti...

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Main Authors: Martono Tri Utomo, -, Ni Luh Putu Herli Mastuti, -, Hodimatum Mahiroh, -, Talitha Aden, -
Format: Article PeerReviewed
Language:English
Indonesian
English
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Online Access:https://repository.unair.ac.id/126263/1/19.%20Artikel.pdf
https://repository.unair.ac.id/126263/2/19%20Karil.pdf
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https://www.researchgate.net/publication/359190088_Clinical_Manifestations_of_Neonatal_Sepsis_and_Antibiotics_Management_in_Newborn_at_Dr_Soetomo_General_Hospital_Surabaya_Indonesia
http://dx.doi.org/10.47119/IJRP100961320222928
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spelling id-langga.1262632023-05-06T05:24:05Z https://repository.unair.ac.id/126263/ Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia. Martono Tri Utomo, - Ni Luh Putu Herli Mastuti, - Hodimatum Mahiroh, - Talitha Aden, - R5-920 Medicine (General) Abstract Background: Neonatal sepsis is a problem of morbidity and mortality that still occurs in neonates. This neonatal sepsis can cause 1/4 of the total deaths in neonates in the world. The incidence can increase to 13-27 cases per 1000 live births in babies born weighing <1500 grams. Objective: This study was conducted to describe laboratory and culture results, clinical manifestations, and antibiotic management in infants diagnosed with neonatal sepsis. Material and Methods: This research is an observational study with a case series retrospective study method. The subjects observed were 9 newborns and diagnosed with sepsis. Data were collected from medical records from June to August 2021. Most of the neonatal sepsis was early-onset, namely 6 neonates. . Results: A total of 4 neonates were included in the Low Birth Weight and 6 neonates were born prematurely. A total of 4 neonates had hyperbilirubinemia, 2 neonates had leukopenia, and 4 neonates had thrombocytopenia. The most common microorganisms causing sepsis in neonates were Acinetobacter baumannii (4), Klebsiella pneumoniae (3), and Staphylococcus epidermidis (3). The most common clinical manifestation is fever (7). For antibiotic treatment, all neonates received initial antibiotic treatment of Ampicillin and Gentamicin with administration between 3-9 days. While the second antibiotic, as many as 7 neonates received antibiotics Cefoperazone sulbactam and Amikacin between 4-18 days. Conclusion: From the results of the study, it can be concluded that culture and laboratory results are important for the proper administration of antibiotics. Surveillance of organisms causing sepsis should also be carried out regularly to plan appropriate treatment. Then there is a need for further research with a longer period to fully describe neonatal sepsis. Increased adherence to antibiotic stewardship also needs to be considered to prevent antibiotic resistance and improve patient outcomes Article PeerReviewed text en https://repository.unair.ac.id/126263/1/19.%20Artikel.pdf text id https://repository.unair.ac.id/126263/2/19%20Karil.pdf text en https://repository.unair.ac.id/126263/3/19%20turnitin.pdf Martono Tri Utomo, - and Ni Luh Putu Herli Mastuti, - and Hodimatum Mahiroh, - and Talitha Aden, - Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia. International Journal of Research Publications, 96 (1). pp. 191-198. ISSN 2708-3578 https://www.researchgate.net/publication/359190088_Clinical_Manifestations_of_Neonatal_Sepsis_and_Antibiotics_Management_in_Newborn_at_Dr_Soetomo_General_Hospital_Surabaya_Indonesia http://dx.doi.org/10.47119/IJRP100961320222928
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
Indonesian
English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
Martono Tri Utomo, -
Ni Luh Putu Herli Mastuti, -
Hodimatum Mahiroh, -
Talitha Aden, -
Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.
description Abstract Background: Neonatal sepsis is a problem of morbidity and mortality that still occurs in neonates. This neonatal sepsis can cause 1/4 of the total deaths in neonates in the world. The incidence can increase to 13-27 cases per 1000 live births in babies born weighing <1500 grams. Objective: This study was conducted to describe laboratory and culture results, clinical manifestations, and antibiotic management in infants diagnosed with neonatal sepsis. Material and Methods: This research is an observational study with a case series retrospective study method. The subjects observed were 9 newborns and diagnosed with sepsis. Data were collected from medical records from June to August 2021. Most of the neonatal sepsis was early-onset, namely 6 neonates. . Results: A total of 4 neonates were included in the Low Birth Weight and 6 neonates were born prematurely. A total of 4 neonates had hyperbilirubinemia, 2 neonates had leukopenia, and 4 neonates had thrombocytopenia. The most common microorganisms causing sepsis in neonates were Acinetobacter baumannii (4), Klebsiella pneumoniae (3), and Staphylococcus epidermidis (3). The most common clinical manifestation is fever (7). For antibiotic treatment, all neonates received initial antibiotic treatment of Ampicillin and Gentamicin with administration between 3-9 days. While the second antibiotic, as many as 7 neonates received antibiotics Cefoperazone sulbactam and Amikacin between 4-18 days. Conclusion: From the results of the study, it can be concluded that culture and laboratory results are important for the proper administration of antibiotics. Surveillance of organisms causing sepsis should also be carried out regularly to plan appropriate treatment. Then there is a need for further research with a longer period to fully describe neonatal sepsis. Increased adherence to antibiotic stewardship also needs to be considered to prevent antibiotic resistance and improve patient outcomes
format Article
PeerReviewed
author Martono Tri Utomo, -
Ni Luh Putu Herli Mastuti, -
Hodimatum Mahiroh, -
Talitha Aden, -
author_facet Martono Tri Utomo, -
Ni Luh Putu Herli Mastuti, -
Hodimatum Mahiroh, -
Talitha Aden, -
author_sort Martono Tri Utomo, -
title Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.
title_short Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.
title_full Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.
title_fullStr Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.
title_full_unstemmed Clinical Manifestations of Neonatal Sepsis and Antibiotics Management in Newborn at Dr. Soetomo General Hospital Surabaya, Indonesia.
title_sort clinical manifestations of neonatal sepsis and antibiotics management in newborn at dr. soetomo general hospital surabaya, indonesia.
url https://repository.unair.ac.id/126263/1/19.%20Artikel.pdf
https://repository.unair.ac.id/126263/2/19%20Karil.pdf
https://repository.unair.ac.id/126263/3/19%20turnitin.pdf
https://repository.unair.ac.id/126263/
https://www.researchgate.net/publication/359190088_Clinical_Manifestations_of_Neonatal_Sepsis_and_Antibiotics_Management_in_Newborn_at_Dr_Soetomo_General_Hospital_Surabaya_Indonesia
http://dx.doi.org/10.47119/IJRP100961320222928
_version_ 1765216287144804352