Associated neonatal and maternal factors of osteopenia of prematurity in low resource setting: A cross-sectional study.

• Main Authors: Dina Angelika, -, Risa Etika, -, Muhammad Pradhika Mapindra, -, Martono Tri Utomo, Martono, Paulus Rahardjo, Paulus, I Dewa Gede Ugrasena, I Dewa
• 格式: Article PeerReviewed
• 語言: English; English; Indonesian
• 出版: Elsevier
• 主題: R5-920 Medicine (General)
• 在線閱讀: https://repository.unair.ac.id/126303/1/9%20text%20journal%20osteopenia.pdf; https://repository.unair.ac.id/126303/2/9%20turnitin%2022%25%20osteopenia.pdf; https://repository.unair.ac.id/126303/3/9.%20Associated%20neonatal%20and%20maternal%20factors%20of%20osteopenia%20of%20prematurity%20in%20low%20resource%20setting_%20A%20cross-sectional%20study.pdf; https://repository.unair.ac.id/126303/; https://www.sciencedirect.com/science/article/pii/S2049080121001850; https://doi.org/10.1016/j.amsu.2021.102235
• 機構: Universitas Airlangga

Abstract Objective Determining neonatal and maternal factors that are associated with the incidence of OFP. Methods This study employed a cross-sectional design, in which the participants were identified for clinical variables (sex, gestational age, birth weight, etc.), neonatal morbidity (sepsis, necrotizing enterocolitis (NEC), etc.), and maternal risk factors (premature rupture of membranes, preeclampsia, etc.). The data were analyzed using Chi-square test, independent t-test, and logistic regression test with p < 0.05. Results The birth weight ranged from 800 to 1495 g (1219 ± 225 g), of which 5 newborns (17%) were <1000 g. The gestational age ranged from 27 to 32 weeks, with a mean of 29 ± 1.5 weeks. The signs of OFP were observed in 13 (43%) infants, of which 2 (15%) OFP infants had a birth weight <1000 g. There was significant difference in parenteral nutrition duration (p = 0.018), onset of vitamin D supplementation (p = 0.019), and ALP level (p = 0.012) of infants between the OFP group and the non-OFP group. The variables associated with the incidence of OFP were parenteral nutrition duration >15 days (OR = 5.4; 95% CI 1.120–26.044; p = 0.036), ALP level >500 U/L (OR = 2.889; 95% CI 1.703–4.900; p = 0.014), and PROM (OR = 5.4; 95% CI 1.039–28.533; p = 0.045). Conclusion The lack of phosphate intake, prolonged parenteral nutrition, ALP level >500 U/L, onset of vitamin D supplementation, and premature rupture of membranes are associated with the incidence of OFP.