Profil Kadar Interleukin-31 Serum pada Pasien Dermatitis Atopik
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic skin lesion. Pathogenesis of AD is not fully understood, but recent studies demonstrate the role of interleukin-31 (IL-31). This cytokine is considered to be a potential mediator inducing pruritus in...
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Format: | Article PeerReviewed |
Language: | English English English |
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Universitas Airlangga
2017
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Online Access: | https://repository.unair.ac.id/126387/1/Similarity%2013.pdf https://repository.unair.ac.id/126387/2/Artikel%2013.pdf https://repository.unair.ac.id/126387/3/Karil%2013.pdf https://repository.unair.ac.id/126387/ https://e-journal.unair.ac.id/BIKK/article/view/5564 https://doi.org/10.20473/bikk.V29.2.2017.142-150 |
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Institution: | Universitas Airlangga |
Language: | English English English |
Summary: | Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic skin lesion. Pathogenesis of AD is not fully understood, but recent studies demonstrate the role of interleukin-31 (IL-31). This cytokine is considered to be a potential mediator inducing pruritus in AD. Several studies reported a direct correlation between serum IL-31 level and severity of AD, probably due to the ability of this cytokine to increase the inflammatory response through the initiation of the expression of proinflammatory cytokines and chemokines. Purpose: To evaluate the serum level of IL-31 in AD patients. Methods: Thirty-four AD patients who defined according to the criteria of United Kingdom (UK) Working Party were included in this descriptive observational cross-sectional study. Samples were taken from peripheral venous blood and IL-31 serum levels were measured using ELISA. Results: Mean IL-31 serum level was 99.43±72.91 pg/mL, with the lowest level of 6.84 pg/mL and the highest level of 281.25 pg/mL. Conclusion: IL-31 seems to have a role in atopic dermatitis but further investigation is required. |
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