A Case Report: Role of Human Amniotic Membrane Mesenchymal Stem Cells-Conditioned Medium (hAMMSC-CM) Combine with Vitamin E for Treating Chronic Plantar Pedis Ulcer in Leprosy Patient

• Main Authors: Marissa Astari, -, Afif Nurul Hidayati, -, Medhi Denisa Alinda, -, Bagus Haryo Kusumaputra, -, Linda Astari, -, Muhammad Yulianto Listiawan, -, Indropo Agusni, -, Fedik Abdul Rantam, -, Sunarso Suyoso, -, Evy Ervianti, -, Yuri Widia, -, Sylvia Anggraeni, -, Cita Rosita Sigit Prakoeswa, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Science and Technology Publications, Lda. All rights reserved 2018
• Subjects: R Medicine (General); RL Dermatology
• Online Access: https://repository.unair.ac.id/126423/1/11.pdf; https://repository.unair.ac.id/126423/2/Artikel%2011.pdf; https://repository.unair.ac.id/126423/3/Similarity%2011.pdf; https://repository.unair.ac.id/126423/; https://www.scitepress.org/Link.aspx?doi=10.5220/0008160504930495
• Institution: Universitas Airlangga

Leprosy ulcers are mostly present in plantar pedis especially in areas with bony prominance. Plantar ulcers healimg in leprosy ide often dificult and time comsuming because of the declining of growth factors and cytokines as a result of a prolonged inflammatory condition. A 70-years old man working as pedicab driver had an ulcer at his left feet since 2 yaers ago, painless and not itchy. On regio caput metatarsal digiti 1 pedis sinistra there were 4 x 4 x 0,4 cm with necrotic tissue around. The patient was suffering from borderline leprosy since 10 years and already finished the treatment without history of drop out. We applied topical human amniotic membrane mesenchymal stem cells-conditioned medium (hAMMSC-CM) combine with vitamin E gel for 5 weeks and the ulcer healed completely.