Neutrophils to Lymphocyte Ratio: Earliest and Efficacious Markers of Sepsis

• Main Authors: AKHMAD NURDANI, NIM010980206, Usman Hadi, -, Muhammad Vitanata Arfijanto, -, Musofa Rusli, -, Bramantono, -, Muhammad Miftahussurur, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Yerevan State Medical University 2019
• Subjects: RC1200 Sports Medicine
• Online Access: https://repository.unair.ac.id/126557/1/13%20%20artikel.pdf; https://repository.unair.ac.id/126557/2/13%20Karil.pdf; https://repository.unair.ac.id/126557/3/13%20Turnitin.pdf; https://repository.unair.ac.id/126557/; https://www.cureus.com/articles/42378-neutrophils-to-lymphocyte-ratio-earliest-and-efficacious-markers-of-sepsis#!/; https://doi.org/10.7759%2Fcureus.10851
• Institution: Universitas Airlangga

background: Mortality in sepsis patients is still quite high. Delayed diagnosis will further inease mortality in septic patients. Microbiological culture examination is a standard diagnosis ofsepsis which takes a relatively long time and low sensitivity. Currently procalcitonin is a reliablebiomarker for the diagnosis and prognosis of sepsis patients. The neutrophil-lymphocyte ratio is asimple test that has been tested as a diagnostic marker for bacterial infection. We determined thecorrelation between neutrofil-limfosit rasio and procalcitonin level in sepsis patiens. Method: This study was an observational analytic with cross-sectional design conducted onsepsis patients aged of 18-60. The neutrophil-lymphocyte ratio was determined using Sysmex XN 1000 hematologyanalyzer. Procalcitonin levels were measured using VIDAS®BRAHMS PCT with the enzyme-linked fluorescence assay principle. The correlation between the ratio of neutrophillymphocytes and procalcitonin levels was statistically analyzed using Spearman correlation test. results: There were 30 subjects enrolled in this study. From microbial culture 63.3%-gramnegative bacteria were identified. Median ratio of neutrophils-lymphocytes and procalcitoninwas 12.05 (6.48-24.27) and 2.85ng/ml (0.75-88.42 ng/ml), respectively. The neutrophil-lymphocyte ratio in gram negative and procalcitonin were 12.07 ± 3.52 and 10.34 ± 22.92 ng/ml, respectively.While that of grams positive was 15.76 ± 4.36, and 6.02 ± 4.26 ng/ml, respectively. Theratio of neutrophils-lymphocytes and procalcitonin in sepsis, severe sepsis, and septic shockwere 10.08 ± 3.34 and 1.79 ± 1.39 ng/ml, 12.11 ± 4.08 and 3.56 ± 2, 79 ng/ml, 15,78 ± 6,10, and23,19 ± 31,33 ng/ml, respectively. Spearman’s correlation test showed a strong and significantcorrelation (rs = 0.68, p <0.01).; p<0.01).between the ratio of neutrophil-limphocytes and prcalcitonin levels in sepsis patients conclusion: There was a strong and significant correlation between the ratio of neutrophillimphocytes and procalcitonin levels in sepsis patients