Oral Candidiasis in Immunosuppressed Wistar Rats (Rattus norvegicus) Post Dexamethasone Injection at 7.2 mg/kg and 16 mg/kg Doses
Objective: Oral candidiasis is an infection that occurs in the oral cavity and is caused by candida species, often Candida albicans. This infection commonly occurs in a condition of immunosuppression caused by dexamethasone. Due to the side effects of antifungal therapy, developing a standardi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
Universidade Estadual Paulista, Insitute of Science and Technology of Sao Jose dos Campo
2020
|
| Subjects: | |
| Online Access: | https://repository.unair.ac.id/126794/1/6.pdf https://repository.unair.ac.id/126794/2/6.pdf https://repository.unair.ac.id/126794/3/6..pdf https://repository.unair.ac.id/126794/ http://www.jidmr.com/journal/wp-content/uploads/2022/09/23-D22_1849_Dian_Agustin_Wahjuningrum_Indonesia.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Objective: Oral candidiasis is an infection
that occurs in the oral cavity and is caused
by candida species, often Candida albicans.
This infection commonly occurs in a
condition of immunosuppression caused by
dexamethasone. Due to the side effects of
antifungal therapy, developing a standardized
immunosuppressed animal model to induce
oral candidiasis for new therapies is required.
The aim of this study is to observe oral
candidiasis in immunosuppressed Wistar rats
post dexamethasone injection at 7.2 mg/kg
and 16 mg/kg doses. Material and Methods:
Twenty-one Wistar rats were divided into
three groups: control group, treatment
group 1 (injected with dexamethasone at a
concentration of 7.2 mg/kg), and treatment
group 2 (at a concentration of 16 mg/kg)
for five days. Immunosuppression status
was observed by leukocyte count and all
the subjects’ palates were inoculated with
C.albicans 0.1 ml of 15x108 UFC/ml 24 hours
later. The subjects’ tongues were observed
and confirmed by laboratory examination on
day 10. A statistical analysis was performed
using one way ANOVA, Kruskal–Wallis, Tukey
HSD, and Mann-Whitney U tests. Results: A
significant clinical appearance of the subjects’
tongues was observed only between C and
T1 (p=0.023;p<0.05). Significant hyphal
formation was observed between C and T1 |
|---|