Allogenous Freeze-Dried Platelet-Rich Plasma Promotes Peripheral Myelin Repair in Chronic Constriction Nerve Injury
Background: Neuropathic pain is a chronic pain condition that refers to all pain that begins or is caused by a primary lesion or dysfunction or a temporary disorder in the peripheral or central nervous system (CNS). Neuropathic pain is caused by damage or injury to nerves that transfer informati...
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| Main Authors: | , , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
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| Online Access: | https://repository.unair.ac.id/126805/1/20.pdf https://repository.unair.ac.id/126805/2/20.pdf https://repository.unair.ac.id/126805/3/20..pdf https://repository.unair.ac.id/126805/ https://www.sysrevpharm.org/articles/allogenous-freezedried-plateletrich-plasma-promotes-peripheral-myelin-repair-in-chronic-constriction-nerve-injury.pdf |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Background: Neuropathic pain is a chronic pain condition that refers
to all pain that begins or is caused by a primary lesion or dysfunction
or a temporary disorder in the peripheral or central nervous system
(CNS). Neuropathic pain is caused by damage or injury to nerves that
transfer information to the brain and spinal cord from the skin,
muscles and other body parts. Platelet concentrates such as Platelet
Rich Plasma (PRP) have been proven very useful for tissue
regeneration since they contain high Growth Factors. PRP is tested
for nerve injury to determine the potential of PRP in improving nerve.
Objective: The purpose of this study is to prove the role of PRP in
increasing the thickness of myelin in the process of repairing nerves
on days 14 and 21.
Methods: This study used three-month-old Rattus novergicus as
experimental animals. Experimental animals were randomly divided
into 7 groups, each consisting of six rats. On day 14 and 21 after
treatment, rats were sacrificed. The examination of myelin thickness
was obtained from Osmium Tetraoxide-Toluidine blue staining.
Analysis of the data was performed with ANOVA test.
Results: The differentiation capability of FD-PRP towards the sciatic
nerve was better in the single dose PRP at 21 days, as indicated by
an increase in axon remyelinization compared with differentiation in
the chronic ligation group. The myelin thicknes was significantly
increased (p 0.000 < 0.05) in FD-PRP groups compared to ligation
group at day 21, whereas myelin thicknes no significantly increased
(p < 0.05) in FD-PP groups compared to control group at day 21.
Conclusion: PRP can increase axon remyelinization in
neuroregeneration. Administration of PRP Single doses for 21 days
show the most effective dose for neuroregeneration. |
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