The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus

Type 1 diabetes mellitus (T1DM) is a disease caused by dysregulation of the immune system with pancreatic cells as the targeted organ. The incidence of T1DM is increasing every year, with peak incidence at the age of 10-14 years. Genetic susceptibility and environmental exposure play important roles...

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Main Authors: Ike Wahyu Triastuti, -, Roedi Irawan, -, Anang Endaryanto, -, Nur Rochmah, -, Muhammad Faizi, -
Format: Article PeerReviewed
Language:English
English
English
Published: International Journal of Scientific Advances (IJSCIA) 2022
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Online Access:https://repository.unair.ac.id/126823/3/30%20-%20Artikel.pdf
https://repository.unair.ac.id/126823/1/30%20-%20Kualitas%20Karil.pdf
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https://repository.unair.ac.id/126823/
https://www.ijscia.com/?p=9572
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spelling id-langga.1268232023-05-29T23:02:20Z https://repository.unair.ac.id/126823/ The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus Ike Wahyu Triastuti, - Roedi Irawan, - Anang Endaryanto, - Nur Rochmah, - Muhammad Faizi, - R Medicine (General) RJ Pediatrics Type 1 diabetes mellitus (T1DM) is a disease caused by dysregulation of the immune system with pancreatic cells as the targeted organ. The incidence of T1DM is increasing every year, with peak incidence at the age of 10-14 years. Genetic susceptibility and environmental exposure play important roles in immune system disorders. The failure of the tolerogenic process is one of the foremost processes causing pancreatic damage through the molecular mimicry process due to repeated infections both prenatally and postnatally. An increase in the expression of MHC class II and co-stimulator will trigger a shift in the balance of the shape of T cells, namely an increase in Th1 and Th7 cell differentiation, but a decrease in the number and function of Treg cells. TGF-β is a cytokine produced by Treg cells that functions to maintain tolerance in the human body. A decrease in TGF-β levels usually appears in the pre-diabetes stage. This review aims to elucidate the role of TGF- in the course of T1DM. International Journal of Scientific Advances (IJSCIA) 2022 Article PeerReviewed text en https://repository.unair.ac.id/126823/3/30%20-%20Artikel.pdf text en https://repository.unair.ac.id/126823/1/30%20-%20Kualitas%20Karil.pdf text en https://repository.unair.ac.id/126823/2/30%20-%20Turnitin.pdf Ike Wahyu Triastuti, - and Roedi Irawan, - and Anang Endaryanto, - and Nur Rochmah, - and Muhammad Faizi, - (2022) The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus. International Journal of Scientific Advances, 3 (2). pp. 280-283. ISSN 2708-7972 https://www.ijscia.com/?p=9572
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
English
topic R Medicine (General)
RJ Pediatrics
spellingShingle R Medicine (General)
RJ Pediatrics
Ike Wahyu Triastuti, -
Roedi Irawan, -
Anang Endaryanto, -
Nur Rochmah, -
Muhammad Faizi, -
The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus
description Type 1 diabetes mellitus (T1DM) is a disease caused by dysregulation of the immune system with pancreatic cells as the targeted organ. The incidence of T1DM is increasing every year, with peak incidence at the age of 10-14 years. Genetic susceptibility and environmental exposure play important roles in immune system disorders. The failure of the tolerogenic process is one of the foremost processes causing pancreatic damage through the molecular mimicry process due to repeated infections both prenatally and postnatally. An increase in the expression of MHC class II and co-stimulator will trigger a shift in the balance of the shape of T cells, namely an increase in Th1 and Th7 cell differentiation, but a decrease in the number and function of Treg cells. TGF-β is a cytokine produced by Treg cells that functions to maintain tolerance in the human body. A decrease in TGF-β levels usually appears in the pre-diabetes stage. This review aims to elucidate the role of TGF- in the course of T1DM.
format Article
PeerReviewed
author Ike Wahyu Triastuti, -
Roedi Irawan, -
Anang Endaryanto, -
Nur Rochmah, -
Muhammad Faizi, -
author_facet Ike Wahyu Triastuti, -
Roedi Irawan, -
Anang Endaryanto, -
Nur Rochmah, -
Muhammad Faizi, -
author_sort Ike Wahyu Triastuti, -
title The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus
title_short The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus
title_full The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus
title_fullStr The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus
title_full_unstemmed The Role of TGF-β in the Pathogenesis of Type 1 Diabetes Mellitus
title_sort role of tgf-β in the pathogenesis of type 1 diabetes mellitus
publisher International Journal of Scientific Advances (IJSCIA)
publishDate 2022
url https://repository.unair.ac.id/126823/3/30%20-%20Artikel.pdf
https://repository.unair.ac.id/126823/1/30%20-%20Kualitas%20Karil.pdf
https://repository.unair.ac.id/126823/2/30%20-%20Turnitin.pdf
https://repository.unair.ac.id/126823/
https://www.ijscia.com/?p=9572
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