Prostate Cancer Microbiome: A Narrative Review of What We Know So Far

• Main Authors: Yudhistira Pradnyan Kloping, Yudhistira, Lukman Hakim, Lukman
• Format: Article PeerReviewed
• Language: English; Indonesian; English; English
• Published: Springer Nature
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/127173/1/06.%20Prostate%20Cancer%20Microbiome.pdf; https://repository.unair.ac.id/127173/2/6.pdf; https://repository.unair.ac.id/127173/3/06.%20Prostate%20Cancer.pdf; https://repository.unair.ac.id/127173/4/06.%20Prostate%20Cancer%20Microbiome.pdf; https://repository.unair.ac.id/127173/; https://link.springer.com/article/10.1007/s40588-022-00178-y; https://doi.org/10.1007/s40588-022-00178-y
• Institution: Universitas Airlangga

Abstract Purpose of review The role of the microbiome in mediating the pathogenesis of prostate cancer has been suggested to have a role in the carcinogenesis process. This review aimed to explore the potential role of the prostate, urinary, and gut microbiomes in prostate cancer development. Recent Findings Current literature indicates that the discovery of microbes, potentially associated with prostate cancer, raises more questions about whether their presence was merely coincidental or due to contamination. Studies have discovered bacteria and viruses in the prostate, urinary tract, and gastrointestinal tract. However, whether there is a prostate microbiome is still unclear due to the study design limitations and small sample size. Summary Even though the link between the specific microbiome and prostate cancer has not been established, findings suggest that chronic inflammation and immune system modulation associated with the microbiome are the underlying mechanisms increasing the risk of prostate cancer development.