The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT)
Abstract: The global incidence of testicular cancer is 1-2% from all cancers. The attempts to maintain high therapeutic rates while decreasing the treatment-related side effects and toxicity have become the current concern. However, the reports regarding testicular germ cell tumors (GCT) in Indon...
Saved in:
Main Authors: | , |
---|---|
Format: | Article PeerReviewed |
Language: | English Indonesian English |
Published: |
Universitas Airlangga
|
Subjects: | |
Online Access: | https://repository.unair.ac.id/127222/1/29.%20The%20prognostic%20role.pdf https://repository.unair.ac.id/127222/2/29.pdf https://repository.unair.ac.id/127222/3/29.%20THE%20PROGNOSTIC.pdf https://repository.unair.ac.id/127222/ https://e-journal.unair.ac.id/FMI/article/view/32599 https://doi.org/10.20473/fmi.v58i1.32599 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | English Indonesian English |
id |
id-langga.127222 |
---|---|
record_format |
dspace |
spelling |
id-langga.1272222023-06-12T08:54:30Z https://repository.unair.ac.id/127222/ The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) Haviv Muris Saputra, - Lukman Hakim, Lukman R5-920 Medicine (General) Abstract: The global incidence of testicular cancer is 1-2% from all cancers. The attempts to maintain high therapeutic rates while decreasing the treatment-related side effects and toxicity have become the current concern. However, the reports regarding testicular germ cell tumors (GCT) in Indonesia are limited. Thus, we aimed to evaluate the clinical characteristics of testicular GCT patients undergoing bleomycin, etoposide, and cisplatin (BEP) chemotherapy, as well as their chemotherapy response and side effects. We reported the data of patients with Testicular Germ Cell Tumor from January 2015 to December 2019. Several data were retrieved, including patient demographics, tumor characteristics, treatment, and prognosis outcome. A total of 67 patients with testicular germ cell tumors were included in this study. The mean age was 28.9 years old. The chemotherapy regimens used were four cycles of (BEP) in 36 patients (53.7%), followed by three cycles of BEP in 22 patients (32.8%). Patients with seminoma GCT mostly had a complete response (54.1%), whereas most patients with non-seminoma GCT had progressive disease (47.8%). The multiple logistic regression analysis showed that NLR and S staging were independently associated with the patient’s response to chemotherapy (OR 2.14, 95% CI 1.22, 3.78, p <0.01,OR 9.43, 95% CI 1.81, 49.14, p < 0.01). The clinical characteristics and response of testicular GCT patients among Indonesian men showed similarity with the current worldwide data. The NLR could be used as a potential biomarker for prognosis. Universitas Airlangga Article PeerReviewed text en https://repository.unair.ac.id/127222/1/29.%20The%20prognostic%20role.pdf text id https://repository.unair.ac.id/127222/2/29.pdf text en https://repository.unair.ac.id/127222/3/29.%20THE%20PROGNOSTIC.pdf Haviv Muris Saputra, - and Lukman Hakim, Lukman The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT). Folia Medica Indonesiana, 58 (1). ISSN pISSN: 2355-8393; eISSN: 2599-056X https://e-journal.unair.ac.id/FMI/article/view/32599 https://doi.org/10.20473/fmi.v58i1.32599 |
institution |
Universitas Airlangga |
building |
Universitas Airlangga Library |
continent |
Asia |
country |
Indonesia Indonesia |
content_provider |
Universitas Airlangga Library |
collection |
UNAIR Repository |
language |
English Indonesian English |
topic |
R5-920 Medicine (General) |
spellingShingle |
R5-920 Medicine (General) Haviv Muris Saputra, - Lukman Hakim, Lukman The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) |
description |
Abstract:
The global incidence of testicular cancer is 1-2% from all cancers. The attempts to maintain high therapeutic rates while decreasing the treatment-related side effects and toxicity have become the current concern. However, the reports regarding testicular germ cell tumors (GCT) in Indonesia are limited. Thus, we aimed to evaluate the clinical characteristics of testicular GCT patients undergoing bleomycin, etoposide, and cisplatin (BEP) chemotherapy, as well as their chemotherapy response and side effects. We reported the data of patients with Testicular Germ Cell Tumor from January 2015 to December 2019. Several data were retrieved, including patient demographics, tumor characteristics, treatment, and prognosis outcome. A total of 67 patients with testicular germ cell tumors were included in this study. The mean age was 28.9 years old. The chemotherapy regimens used were four cycles of (BEP) in 36 patients (53.7%), followed by three cycles of BEP in 22 patients (32.8%). Patients with seminoma GCT mostly had a complete response (54.1%), whereas most patients with non-seminoma GCT had progressive disease (47.8%). The multiple logistic regression analysis showed that NLR and S staging were independently associated with the patient’s response to chemotherapy (OR 2.14, 95% CI 1.22, 3.78, p <0.01,OR 9.43, 95% CI 1.81, 49.14, p < 0.01). The clinical characteristics and response of testicular GCT patients among Indonesian men showed similarity with the current worldwide data. The NLR could be used as a potential biomarker for prognosis. |
format |
Article PeerReviewed |
author |
Haviv Muris Saputra, - Lukman Hakim, Lukman |
author_facet |
Haviv Muris Saputra, - Lukman Hakim, Lukman |
author_sort |
Haviv Muris Saputra, - |
title |
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) |
title_short |
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) |
title_full |
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) |
title_fullStr |
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) |
title_full_unstemmed |
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in testicular germ cell tumor (GCT) |
title_sort |
prognostic role of neutrophil-to-lymphocyte ratio (nlr) in testicular germ cell tumor (gct) |
publisher |
Universitas Airlangga |
url |
https://repository.unair.ac.id/127222/1/29.%20The%20prognostic%20role.pdf https://repository.unair.ac.id/127222/2/29.pdf https://repository.unair.ac.id/127222/3/29.%20THE%20PROGNOSTIC.pdf https://repository.unair.ac.id/127222/ https://e-journal.unair.ac.id/FMI/article/view/32599 https://doi.org/10.20473/fmi.v58i1.32599 |
_version_ |
1769840079200583680 |