Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi
Carbofuran is a broad spectrum carbamat insecticide which is used in various farm practices. An exposure of carbofuran has been reported able to induce Reactive Oxygen Species (ROS) or free radical in kidney. Free radical caused cells damage. The present study was designed to investigate the effect...
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id-langga.1272702023-06-14T22:09:58Z https://repository.unair.ac.id/127270/ Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi Edi Purnomo, - Epy Muhammad Luqman, - Hermin Ratnani, - Hani Plumeriastuti, - Maslichah Mafruchati, - Yeni Dhamayanti, - SF405.5-407 Laboratory animals SF811-909 Veterinary medicine of special organs, regions, and systems Carbofuran is a broad spectrum carbamat insecticide which is used in various farm practices. An exposure of carbofuran has been reported able to induce Reactive Oxygen Species (ROS) or free radical in kidney. Free radical caused cells damage. The present study was designed to investigate the effect of carbofuran in kidneys histopathologic of mice pup whose dam were exposed by carbofuran during the lactation period. High levels of ROS can bind to various biomolecules such as proteins, lipids and nucleic acids so that carbofuran has a negative effect on tissue functions and structures. Free radical caused changes in the pathological conditions of the tissue including the kidneys. The dams were devided into four groups of five animals each. P0 animal group was received aquadest 0,1 ml per body weight (BW), P1 animal group was treated carbofuran at the dose of 1/16 LD50 (0,3125 mg per BW), P2 animal group was treated carbofuran at the dose of 1/8 LD50 (0, 625 mg per BW), and P3 animal group was treated carbofuran at the dose of 1/4 LD50 (1,25 mg per BW). The carbofuran was exposed via oral postnatal day 1st until 9thpostnatal day after delivery. At postnatal day 10th, offspring were sacrified. The kidney of mice pup was collected and processed for microscopic examination with hematoxilin-eosin staining. Microscopic observations on the histology of the mice pup kidney showed an increase in the degree of kidney damage as an increase in the dose of carbofuran given to the dams. The results showed tubular changes in the form of tubular degeneration, inflammatory cell infiltration and tubular necrosis in the kidney of mice pups Fakultas Kedokteran Hewan Universitas Airlangga 2020-06 Article PeerReviewed text en https://repository.unair.ac.id/127270/1/Artikel_52_Hani_Plumeriastuti.pdf text en https://repository.unair.ac.id/127270/2/Kesesuaian_52_Hani_Plumeriastuti.pdf Edi Purnomo, - and Epy Muhammad Luqman, - and Hermin Ratnani, - and Hani Plumeriastuti, - and Maslichah Mafruchati, - and Yeni Dhamayanti, - (2020) Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi. Journal of Basic Medical Veterinary, 9 (1). pp. 54-62. ISSN 2302-6820, E-ISSN 2774-9959 |
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SF405.5-407 Laboratory animals SF811-909 Veterinary medicine of special organs, regions, and systems |
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SF405.5-407 Laboratory animals SF811-909 Veterinary medicine of special organs, regions, and systems Edi Purnomo, - Epy Muhammad Luqman, - Hermin Ratnani, - Hani Plumeriastuti, - Maslichah Mafruchati, - Yeni Dhamayanti, - Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi |
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Carbofuran is a broad spectrum carbamat insecticide which is used in various farm practices. An exposure of carbofuran has been reported able to induce Reactive Oxygen Species (ROS) or free radical in kidney. Free radical caused cells damage. The present study was designed to investigate the effect of carbofuran in kidneys histopathologic of mice pup whose dam were exposed by carbofuran during the lactation period. High levels of ROS can bind to various biomolecules such as proteins, lipids and nucleic acids so that carbofuran has a negative effect on tissue functions and structures. Free radical caused changes in the pathological conditions of the tissue including the kidneys. The dams were devided into four groups of five animals each. P0 animal group was received aquadest 0,1 ml per body weight (BW), P1 animal group was treated carbofuran at the dose of 1/16 LD50 (0,3125 mg per BW), P2 animal group was treated carbofuran at the dose of 1/8 LD50 (0, 625 mg per BW), and P3 animal group was treated carbofuran at the dose of 1/4 LD50 (1,25 mg per BW). The carbofuran was exposed via oral postnatal day 1st until 9thpostnatal day after delivery. At postnatal day 10th, offspring were sacrified. The kidney of mice pup was collected and processed for microscopic examination with hematoxilin-eosin staining. Microscopic observations on the histology of the mice pup kidney showed an increase in the degree of kidney damage as an increase in the dose of carbofuran given to the dams. The results showed tubular changes in the form of tubular degeneration, inflammatory cell infiltration and tubular necrosis in the kidney of mice pups |
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Article PeerReviewed |
author |
Edi Purnomo, - Epy Muhammad Luqman, - Hermin Ratnani, - Hani Plumeriastuti, - Maslichah Mafruchati, - Yeni Dhamayanti, - |
author_facet |
Edi Purnomo, - Epy Muhammad Luqman, - Hermin Ratnani, - Hani Plumeriastuti, - Maslichah Mafruchati, - Yeni Dhamayanti, - |
author_sort |
Edi Purnomo, - |
title |
Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi |
title_short |
Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi |
title_full |
Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi |
title_fullStr |
Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi |
title_full_unstemmed |
Pengaruh Pemaparan Karbofuran pada Induk Mencit (Mus musculus) terhadap Gambaran Histopatologi Ginjal Anak Mencit Masa Laktasi |
title_sort |
pengaruh pemaparan karbofuran pada induk mencit (mus musculus) terhadap gambaran histopatologi ginjal anak mencit masa laktasi |
publisher |
Fakultas Kedokteran Hewan Universitas Airlangga |
publishDate |
2020 |
url |
https://repository.unair.ac.id/127270/1/Artikel_52_Hani_Plumeriastuti.pdf https://repository.unair.ac.id/127270/2/Kesesuaian_52_Hani_Plumeriastuti.pdf https://repository.unair.ac.id/127270/ |
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1769840087486431232 |