Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas
Abstract Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dy...
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id-langga.1272742023-06-13T02:38:04Z https://repository.unair.ac.id/127274/ Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas Flora Ramona Sigit Prakoesw, - Faradiba Maharani, - Munawaroh Fitriah, - Jusak Nugraha, - Hardyanto Soebono, - Budi Prasetyo, Budi Santi Martini, - Dominicus Husada, - Hari Basuki Notobroto, - Muhammad Yulianto Listiawan, - Anang Endaryanto, - Cita Rosita Sigit Prakoeswa, - R5-920 Medicine (General) Abstract Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (), where higher FOXP3+ is observed in the healthy children living in endemic areas group. Hindawi Limited Article PeerReviewed text en https://repository.unair.ac.id/127274/1/23.%20COMPARISON%20OF%20IL%20-17%20AND%20FOXP3.pdf text id https://repository.unair.ac.id/127274/2/23.pdf text en https://repository.unair.ac.id/127274/3/23.%20COMPARISON%20OF%20IL%20-17%20AND%20FOXP3.pdf Flora Ramona Sigit Prakoesw, - and Faradiba Maharani, - and Munawaroh Fitriah, - and Jusak Nugraha, - and Hardyanto Soebono, - and Budi Prasetyo, Budi and Santi Martini, - and Dominicus Husada, - and Hari Basuki Notobroto, - and Muhammad Yulianto Listiawan, - and Anang Endaryanto, - and Cita Rosita Sigit Prakoeswa, - Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas. Interdisciplinary Perspectives on Infectious Diseases, 2021. ISSN 8879809 https://www.hindawi.com/journals/ipid/2021/8879809/ https://doi.org/10.1155/2021/8879809 |
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R5-920 Medicine (General) Flora Ramona Sigit Prakoesw, - Faradiba Maharani, - Munawaroh Fitriah, - Jusak Nugraha, - Hardyanto Soebono, - Budi Prasetyo, Budi Santi Martini, - Dominicus Husada, - Hari Basuki Notobroto, - Muhammad Yulianto Listiawan, - Anang Endaryanto, - Cita Rosita Sigit Prakoeswa, - Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
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Abstract
Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (), where higher FOXP3+ is observed in the healthy children living in endemic areas group. |
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Article PeerReviewed |
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Flora Ramona Sigit Prakoesw, - Faradiba Maharani, - Munawaroh Fitriah, - Jusak Nugraha, - Hardyanto Soebono, - Budi Prasetyo, Budi Santi Martini, - Dominicus Husada, - Hari Basuki Notobroto, - Muhammad Yulianto Listiawan, - Anang Endaryanto, - Cita Rosita Sigit Prakoeswa, - |
author_facet |
Flora Ramona Sigit Prakoesw, - Faradiba Maharani, - Munawaroh Fitriah, - Jusak Nugraha, - Hardyanto Soebono, - Budi Prasetyo, Budi Santi Martini, - Dominicus Husada, - Hari Basuki Notobroto, - Muhammad Yulianto Listiawan, - Anang Endaryanto, - Cita Rosita Sigit Prakoeswa, - |
author_sort |
Flora Ramona Sigit Prakoesw, - |
title |
Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_short |
Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_full |
Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_fullStr |
Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_full_unstemmed |
Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_sort |
comparison of il-17 and foxp3+ levels in maternal and children leprosy patients in endemic and nonendemic areas |
publisher |
Hindawi Limited |
url |
https://repository.unair.ac.id/127274/1/23.%20COMPARISON%20OF%20IL%20-17%20AND%20FOXP3.pdf https://repository.unair.ac.id/127274/2/23.pdf https://repository.unair.ac.id/127274/3/23.%20COMPARISON%20OF%20IL%20-17%20AND%20FOXP3.pdf https://repository.unair.ac.id/127274/ https://www.hindawi.com/journals/ipid/2021/8879809/ https://doi.org/10.1155/2021/8879809 |
_version_ |
1769840088192122880 |