The Effect of Kebar Grass (Biophtyum petersianum Klotzsch) Extract on the Number of Leydig Cells of Mice (Mus Musculus) Treated with TCDD

• Main Authors: Milla Nursadida, -, Hani Plumeriastuti, -, Yeni Dhamayanti, -, Widjiati, -, Epy Muhammad Luqman, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: 2020
• Subjects: SF405.5-407 Laboratory animals; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: https://repository.unair.ac.id/127357/4/Artikel_28_Hani_Plumeriastuti.pdf; https://repository.unair.ac.id/127357/1/Kesesuaian_28_Hani_Plumeriastuti.pdf; https://repository.unair.ac.id/127357/2/Similarity_28_Hani_Plumeriastuti.pdf; https://repository.unair.ac.id/127357/
• Institution: Universitas Airlangga

This study aimed to examine the effect of kebar grass extract on the Leydig cells number of mice to exposed 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). These animals were divided into five groups. Twenty five BALB/C mice were used with five groups: Negative Control (C-), Positive Control (C+) with TCDD 7µg/kgBW IP, and treatment groups that treated with TCDD 7µg/kgBW IP and Kebar Grass orally for 53 days were presented T1 0,045mg/gBW/day, T2 0,080mg/gBW/day, and T3 0,135mg/gBW/day. Results showed that TCDD decreased the Leydig cells number, while kebar grass extract was increase the number of Leydig cells exposed by TCCD significantly (p<0,05). But the increase in the number of Leydig cells had not yet reached the normal number of Leydig cells