Correlation between Blood and Cerebrospinal Fluid (CSF) Neutrophil-Lymphocyte Ratio With Bacterial Meningitis Prognosis Patient

• Main Authors: Paulus Sugianto, Paulus, Abdulloh Machin, -, Devi Ariani Sudibyo, -, Muhammad Hamdan, -
• Format: Article PeerReviewed
• Language: English; Indonesian; English; English
• Published: Universitas Aisyah Pringsewu Lampung
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/127414/1/01.%20Artikel.pdf; https://repository.unair.ac.id/127414/2/01.%20karil.pdf; https://repository.unair.ac.id/127414/3/01.%20Koresponden.pdf; https://repository.unair.ac.id/127414/4/01.%20turnitin.pdf; https://repository.unair.ac.id/127414/; https://aisyah.journalpress.id/index.php/jika/article/view/8267; http://dx.doi.org/10.30604/jika.v8i2.1993
• Institution: Universitas Airlangga

Abstract Bacterial Meningitis is a bacterial infection of the central nervous system’s protective membranes called the meninges. Bacterial Meningitis has a high disability and case fatality rate. This inflammatory process not only manifests in CSF but also systemically. The neutrophil-lymphocyte ratio(NLR) can be a predicting factor of severity and prognosis in systemic inflammation. Only a few studies in Indonesia evaluate the neutrophil-lymphocyte ratio as a predictor of mortality in adult bacterial meningitis. This study also aimed to compare neutrophil-lymphocyte ratio in LCS and systemic as a predictor of mortality in patients with adult bacterial meningitis. This is an analytic cross-sectional study in Dr. Soetomo's general hospital—a total sample of 44 bacterial meningitis patients from the inpatient ward of Dr. Soetomo General Hospital Surabaya. The blood Neutrophil- Lymphocyte ratio, Glasgow Coma Scale upon admission, and Absolute lymphocyte count were significant with bacterial meningitis outcome with p-value less than 0.05. Early detection of bacterial meningitis patient prognosis could alert the healthcare provider to give careful monitoring and aggressive treatment.