Diagnostic Value of 14C Urea Breath Test for Helicobacter pylori Detection Compared by Histopathology in Indonesian Dyspeptic Patients
Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as 14C Urea Breath Test (UBT), is more favorable; however, this partic...
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Main Authors: | , , |
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Format: | Article PeerReviewed |
Language: | English English English |
Published: |
Dove Medical Press Ltd
2021
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Subjects: | |
Online Access: | https://repository.unair.ac.id/127480/1/jurnal%20INTER-2.pdf https://repository.unair.ac.id/127480/2/K-INTER-2.pdf https://repository.unair.ac.id/127480/3/T-INTER-2.pdf https://repository.unair.ac.id/127480/ |
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Institution: | Universitas Airlangga |
Language: | English English English |
Summary: | Purpose: Histopathology method is often used as a gold standard diagnostic for
Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure
which is limited in Indonesia. A non-invasive method, such as 14C Urea Breath Test (UBT),
is more favorable; however, this particular method has not been validated yet.
Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and
14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa
staining of two gastric biopsies (from the antrum and corpus) were evaluated following the
Updated Sydney System.
Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value
was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the
optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity,
92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive
likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy.
Conclusion: The 14C-UBT is an accurate test for H. pylori diagnosis with excellent
sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that
a validation is absolutely necessary for new test prior application to the new population. |
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