Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis
Disseminated histoplasmosis is a severe manifestation of fungal infection caused by Histoplasma capsulatum. It usually occurs in a patient with an immunodeficiency state. With the increase of HIV infection and the use of immunosuppressant drugs lately, its prevalence also increases. A case of 43 y...
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Association of Clinical Pathologists
2021
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id-langga.1275192023-06-22T12:54:02Z https://repository.unair.ac.id/127519/ Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis Paulus Budiono Notopuro Arifoel Hajat Made Putra Sedana RB Pathology Disseminated histoplasmosis is a severe manifestation of fungal infection caused by Histoplasma capsulatum. It usually occurs in a patient with an immunodeficiency state. With the increase of HIV infection and the use of immunosuppressant drugs lately, its prevalence also increases. A case of 43 years old female with prolonged fever, pancytopenia, and massive progressive splenomegaly. The diagnosis of disseminated histoplasmosis and the secondary hemophagocytic syndrome was made based on bone marrow examination that showed increased hemophagocytic processes and multiple intracytoplasmic H.capsulatum. She had been treated with Itraconazole 200 mg for three months. In the first month's evaluation, her complete blood count improved without any transfusions, and the size of her spleen size decreased. She had been fully recovered after the completion of 3-month treatment. Association of Clinical Pathologists 2021 Article PeerReviewed text en https://repository.unair.ac.id/127519/1/jurnal%20Pancytopenia%20and%20Progressive%20Splenomegaly%20in%20Patient%20with.pdf text en https://repository.unair.ac.id/127519/2/karil%20Pancytopenia%20and%20Progressive.pdf text en https://repository.unair.ac.id/127519/3/Pancytopenia%20and%20Progressive.pdf Paulus Budiono Notopuro and Arifoel Hajat and Made Putra Sedana (2021) Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis. Indonesian Journal of Clinical Pathology and Medical Laboratory, 27 (2). pp. 228-231. ISSN p-ISSN: 0854-4263 e-ISSN: 2477-4685 |
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Disseminated histoplasmosis is a severe manifestation of fungal infection caused by Histoplasma capsulatum. It usually
occurs in a patient with an immunodeficiency state. With the increase of HIV infection and the use of immunosuppressant
drugs lately, its prevalence also increases. A case of 43 years old female with prolonged fever, pancytopenia, and massive
progressive splenomegaly. The diagnosis of disseminated histoplasmosis and the secondary hemophagocytic syndrome
was made based on bone marrow examination that showed increased hemophagocytic processes and multiple
intracytoplasmic H.capsulatum. She had been treated with Itraconazole 200 mg for three months. In the first month's
evaluation, her complete blood count improved without any transfusions, and the size of her spleen size decreased. She had
been fully recovered after the completion of 3-month treatment. |
format |
Article PeerReviewed |
author |
Paulus Budiono Notopuro Arifoel Hajat Made Putra Sedana |
author_facet |
Paulus Budiono Notopuro Arifoel Hajat Made Putra Sedana |
author_sort |
Paulus Budiono Notopuro |
title |
Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis |
title_short |
Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis |
title_full |
Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis |
title_fullStr |
Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis |
title_full_unstemmed |
Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis |
title_sort |
pancytopenia and progressive splenomegaly in patient with disseminated histoplasmosis |
publisher |
Association of Clinical Pathologists |
publishDate |
2021 |
url |
https://repository.unair.ac.id/127519/1/jurnal%20Pancytopenia%20and%20Progressive%20Splenomegaly%20in%20Patient%20with.pdf https://repository.unair.ac.id/127519/2/karil%20Pancytopenia%20and%20Progressive.pdf https://repository.unair.ac.id/127519/3/Pancytopenia%20and%20Progressive.pdf https://repository.unair.ac.id/127519/ |
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