Synthesis and characterization of breast-phantom-based gelatine-glutaraldehyde-TiO2 as a test material for the application of breast cancer diagnosis

• Main Authors: Nuril Ukhrowiyah*, .-, Novi Setyaningsih, .-, Dyah Hikmawati, .-, Moh Yasin, .-
• Format: Book Section PeerReviewed
• Language: English; English; English
• Published: AIP Publishing 2017
• Subjects: Q Science; Q Science (General); QC Physics; QC1 Physics (General)
• Online Access: https://repository.unair.ac.id/127560/1/C13.%20Fulltext.pdf; https://repository.unair.ac.id/127560/2/C13.%20Penilaian%20dan%20Validasi.pdf; https://repository.unair.ac.id/127560/3/C13.%20Similarity_.pdf; https://repository.unair.ac.id/127560/; https://iopscience.iop.org/article/10.1088/1742-6596/853/1/012028
• Institution: Universitas Airlangga

Synthesis of breast-phantom-based on gelatine-glutaraldehyde-TiO2 as testing material of breast cancer diagnosis using Near Infrared-Diffuse Optical Tomography (NIR-DOT) is presented. Glutaraldehyde (GA) is added to obtain optimum breast phantom which has same elasticity modulus with mammae. First, synthesis is conducted by mixing gelatine with various amounts of 1 g, 2 g and 3 g with saline solution on 40° C temperature for 30 minutes until they become homogenous. Next, GA with concentration of 0.5 and 1.0% is added. The characterization includes FTIR test, physical test, and mechanical test used to identify group of gelatine's functions. Elasticity modulus of breast phantom of gelatine composition 2 g and 0.5% GA is obtained at 53.46 kPA which is the approximation of mammae culture elasticity. This composition is chosen to synthesise the next step. In the second step, TiO2 is added with variation of 0.01 g, 0.015 g, 0.02 g, 0.025 g, and 0,03 g. With this variation, it is aimed to get a breast phantom providing image with optimum absorption. The test of this material uses Differential Scanning Calorimetry (DSC), homogeneity test, and analysis of coefficient absorption. The result shows the sample has a good thermal property in the range of 40 – 70° C with a good homogeneity and absorption coefficient of 0.4 mm-1.