The glycemic control among type 1 diabetes children pre and during COVID-19 pandemic: A systematic review and meta-analysis

• Main Authors: Wika Yuli Deakandi, -, Farahdina, -, Qurrota Ayuni Novia Putri, -, Tyas Maslakhatien Nuzula, -, Katherine Fedora, -, Qorri ‘Aina, -, Nur Rochmah, -, Muhammad Faizi, -
• Format: Article PeerReviewed
• Language: English; English; English; English; English
• Published: Renaissance Medical Publishing 2022
• Subjects: R Medicine (General); RJ Pediatrics
• Online Access: https://repository.unair.ac.id/127587/1/27%20-%20Artikel.pdf; https://repository.unair.ac.id/127587/2/27%20-%20Korespondensi.pdf; https://repository.unair.ac.id/127587/3/27%20-%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/127587/4/27%20-%20Turnitin.pdf; https://repository.unair.ac.id/127587/8/Karil%20-%20The%20glycemic%20control%20among%20type%201%20diabetes%20children%20pre%20and%20during%20COVID-19%20pandemic%20A%20systematic%20review%20and%20meta-analysis.pdf; https://repository.unair.ac.id/127587/; https://sciencescholar.us/journal/index.php/ijhs/article/view/12893
• Institution: Universitas Airlangga

The impact of the COVID-19 pandemic on glycemic control in Type 1 Diabetes Mellitus (T1DM) patients is still evolving. This study aims to assess the negative effect of the COVID-19 pandemic on mean glucose and glycated hemoglobin (HbA1c) in patients with T1DM. This meta-analysis study using the PRISMA framework method with the search strategy according to the population, intervention, control, and outcome (PICO) model. Relevant articles were searched in 4 databases. The results identified the HbA1c and mean glucose. The COVID-19 pandemic caused an increase in the HbA1c levels (%) compared to the pre-COVID group with a mean difference of -1.06 (95% CI: -1.44, -0.69; p<0.00001). Meanwhile, the mean glucose (mg/dL) decreased during-COVID-19 pandemic with a mean difference of -2.32 (95% CI: -4.40, -0.23; p=0.03). Ten studies with a total of 1615 subjects contributed for HbA1c analysis (during-COVID-19, n = 615; pre-COVID, n = 1000). A total of 1164 patients from six studies with a mean glucose analysis were included (during-COVID-19, n = 418; pre-COVID, n = 746). This study found that the COVID-19 pandemic significantly increased the levels of HbA1c and decreased mean glucose in patients with T1DM, but further studies need to be evaluated.