Electrocardiography on admission is associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis

• Main Authors: Mochamad Yusuf Alsagaff, -, Yudi Her Oktaviono, -, Budi Baktijasa Dharmadjati, -, Achmad Lefi, Achmad, Makhyan Jibril Al-Farabi, -, Parama Gandi, -, Bagas Adhimurda Marsudi, -, Yusuf Azmi, -
• Format: Article PeerReviewed
• Language: English; Indonesian; English
• Published: Wiley-Blackwell 2021
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/128143/1/6.%20Electrocardiography%20on%20admission.pdf; https://repository.unair.ac.id/128143/2/6.pdf; https://repository.unair.ac.id/128143/3/6.%20Electrocardiography%20on%20admission.pdf; https://repository.unair.ac.id/128143/; https://onlinelibrary.wiley.com/doi/10.1002/joa3.12573; https://doi.org/10.1002/joa3.12573
• Institution: Universitas Airlangga

Abstract Background Electrocardiogram (ECG) is a widely accessible diagnostic tool that can easily be obtained on admission and can reduce excessive contact with coronavirus disease 2019 (COVID-19) patients. A systematic review and meta-analysis were performed to evaluate the latest evidence on the association of ECG on admission and the poor outcomes in COVID-19. Methods A literature search was conducted on online databases for observational studies evaluating ECG parameters and composite poor outcomes comprising ICU admission, severe illness, and mortality in COVID-19 patients. Results A total of 2,539 patients from seven studies were included in this analysis. Pooled analysis showed that a longer corrected QT (QTc) interval and more frequent prolonged QTc interval were associated with composite poor outcome ([WMD 6.04 [2.62-9.45], P = .001; I2:0%] and [RR 1.89 [1.52-2.36], P < .001; I2:17%], respectively). Patients with poor outcome had a longer QRS duration and a faster heart rate compared with patients with good outcome ([WMD 2.03 [0.20-3.87], P = .030; I2:46.1%] and [WMD 5.96 [0.96-10.95], P = .019; I2:55.9%], respectively). The incidence of left bundle branch block (LBBB), premature atrial contraction (PAC), and premature ventricular contraction (PVC) were higher in patients with poor outcome ([RR 2.55 [1.19-5.47], P = .016; I2:65.9%]; [RR 1.94 [1.32-2.86], P = .001; I2:62.8%]; and [RR 1.84 [1.075-3.17], P = .026; I2:70.6%], respectively). T-wave inversion and ST-depression were more frequent in patients with poor outcome ([RR 1.68 [1.31-2.15], P < .001; I2:14.3%] and [RR 1.61 [1.31-2.00], P < .001; I2:49.5%], respectively). Conclusion Most ECG abnormalities on admission are significantly associated with an increased composite poor outcome in patients with COVID-19.