Expression of Vascular Endothelial Growth Factor (VEGF) and New Blood Vessels Formation on Wound Incision Post Ropivacaine Administration in Animal Model
Abstract Background: Surgical incision wounds causing clinical pain. Inadequate postoperative pain management resulting in impaired wound healing. A critical factor in wound healing is angiogenesis. VEGF is one of the important factors and regulators of angiogenesis. The aim of this stu...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian English Indonesian |
| Published: |
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| Online Access: | https://repository.unair.ac.id/128276/1/15.%20Expression%20of%20Vascular%20Endothelial%20Growth.pdf https://repository.unair.ac.id/128276/2/%2815%29.pdf https://repository.unair.ac.id/128276/3/15.%20Expression%20of%20Vascular%20Endothelial%20Growth.pdf https://repository.unair.ac.id/128276/6/Bukti%20C.15.pdf https://repository.unair.ac.id/128276/ https://www.ijisrt.com/expression-of-vascular-endothelial-growth-factor-vegf-and-new-blood-vessels-formation-on-wound-incision-post-ropivacaine-administration-in-animal-model |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English Indonesian |
| Summary: | Abstract
Background:
Surgical incision wounds causing clinical pain.
Inadequate postoperative pain management resulting in
impaired wound healing. A critical factor in wound
healing is angiogenesis. VEGF is one of the important
factors and regulators of angiogenesis. The aim of this
study is to analyze the effect of infiltration ropivacaine
on VEGF expression, and the formation of new blood
vessels, which is very instrumental in the wound healing
process.
Methods:
Twenty-four Wistar rats were divided into two
groups, and then superficial-thickness excisional
wounds were created. One was treated by ropivacaine
infiltration, and the other was not given ropivacaine
infiltration as control group. Each of the groups was
divided into two subgroups. Each of the subgroups
composed of 6 Wistar rats based on the period of
termination: 3rd, 7th day after wounding. Histological
evaluation was done to determine the presence of new
small blood vessels and the expression of VEGF of
capillary endothelial cells. The data collected is then
analysed by SPSS.
Results:
The administration of ropivacaine infiltration on
superficial-thickness excisional wounds improved
wound healing characterized by neovascularization
formed and changed of expression of VEGF within
cytoplasm or surface of endothelial cells
Conclusion:
The administration of ropivacaine infiltration has
a beneficial effect on the healing process of superficia |
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