Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis
Abstract: Introduction: Hepatitis B virus (HBV) infection is a major global health issues and one of the most dangerous viral infections with a high mortality rate. Newborns and infant vaccination against chronic HBV infection are crucial for preventing mother-to-child transmission (MTCT). This stu...
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Pharmacognosy Network Worldwide
2023
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id-langga.1300022024-02-06T02:27:35Z https://repository.unair.ac.id/130002/ Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis Aldila Pratiwi, - Bagus Setyoboedi, Bagus Citrawati D. K. Wungu, - R5-920 Medicine (General) Abstract: Introduction: Hepatitis B virus (HBV) infection is a major global health issues and one of the most dangerous viral infections with a high mortality rate. Newborns and infant vaccination against chronic HBV infection are crucial for preventing mother-to-child transmission (MTCT). This study aimed to conduct a meta-analysis to investigate the factors affecting long-term protection against Hepatitis B Immunization in infancy. Material and Methods: Our literature searches are from PubMed, Science Direct, Web of Science, and ProQuest publications between January 2000 and December 2021. The included literature assessed the risk of bias using the Newcastle Ottawa Quality Assessment Scale. We identify Hepatitis B surface antibodies (anti-HBs) ≥ 10 mIU/mL as being protective against HBV infection. The results are combined with a random effect or fixed effect model. Results: Eighteen eligible observational studies with a total of 16,642 participants were included. Analysis of factors affecting long-term protection status by assessing anti-HBs titers showed significant results on several factors, including gestational age for anti-HBs titers (OR 2.5; 95% CI 1.62-3.85; p<0.0001), weight for age to anti-HBs titers (OR 1.36; 95% CI 1.06-1.75; p=0.02), length for age to anti-HBs titers (OR 0.01; 95% CI 0.01-0.02; p<0.00001), and immunization status based on the number of vaccine doses (4 doses vs 3 doses) to anti-HBs titers (p<0.00001). Conclusions: Anti-HBs titers of hepatitis B immunization were significantly affected by gestational age, weight for age, length for age, and vaccine doses. Parents of newborns must be informed about basic immunization and provide adequate nutritional intake to the mother and babies to prevent HBV infection. Pharmacognosy Network Worldwide 2023 Article PeerReviewed text en https://repository.unair.ac.id/130002/1/03.%20artikel.pdf text en https://repository.unair.ac.id/130002/2/3%20karil.pdf text en https://repository.unair.ac.id/130002/3/03.%20turnitin.pdf text en https://repository.unair.ac.id/130002/4/03.%20korespondensi.pdf Aldila Pratiwi, - and Bagus Setyoboedi, Bagus and Citrawati D. K. Wungu, - (2023) Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis. Pharmacognosy Journal, 15 (3). pp. 385-394. ISSN 0975-3575 https://www.phcogj.com/article/2045 http://dx.doi.org/10.5530/pj.2023.15.89 |
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Abstract:
Introduction: Hepatitis B virus (HBV) infection is a major global health issues and one of the most dangerous viral infections with a high mortality rate. Newborns and infant vaccination against chronic HBV infection are crucial for preventing mother-to-child transmission (MTCT). This study aimed to conduct a meta-analysis to investigate the factors affecting long-term protection against Hepatitis B Immunization in infancy. Material and Methods: Our literature searches are from PubMed, Science Direct, Web of Science, and ProQuest publications between January 2000 and December 2021. The included literature assessed the risk of bias using the Newcastle Ottawa Quality Assessment Scale. We identify Hepatitis B surface antibodies (anti-HBs) ≥ 10 mIU/mL as being protective against HBV infection. The results are combined with a random effect or fixed effect model. Results: Eighteen eligible observational studies with a total of 16,642 participants were included. Analysis of factors affecting long-term protection status by assessing anti-HBs titers showed significant results on several factors, including gestational age for anti-HBs titers (OR 2.5; 95% CI 1.62-3.85; p<0.0001), weight for age to anti-HBs titers (OR 1.36; 95% CI 1.06-1.75; p=0.02), length for age to anti-HBs titers (OR 0.01; 95% CI 0.01-0.02; p<0.00001), and immunization status based on the number of vaccine doses (4 doses vs 3 doses) to anti-HBs titers (p<0.00001). Conclusions: Anti-HBs titers of hepatitis B immunization were significantly affected by gestational age, weight for age, length for age, and vaccine doses. Parents of newborns must be informed about basic immunization and provide adequate nutritional intake to the mother and babies to prevent HBV infection. |
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Article PeerReviewed |
author |
Aldila Pratiwi, - Bagus Setyoboedi, Bagus Citrawati D. K. Wungu, - |
author_facet |
Aldila Pratiwi, - Bagus Setyoboedi, Bagus Citrawati D. K. Wungu, - |
author_sort |
Aldila Pratiwi, - |
title |
Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis |
title_short |
Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis |
title_full |
Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis |
title_fullStr |
Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis |
title_full_unstemmed |
Factors Affecting the Long-Term Protection Against Hepatitis B Immunization in Infancy: A Meta-Analysis |
title_sort |
factors affecting the long-term protection against hepatitis b immunization in infancy: a meta-analysis |
publisher |
Pharmacognosy Network Worldwide |
publishDate |
2023 |
url |
https://repository.unair.ac.id/130002/1/03.%20artikel.pdf https://repository.unair.ac.id/130002/2/3%20karil.pdf https://repository.unair.ac.id/130002/3/03.%20turnitin.pdf https://repository.unair.ac.id/130002/4/03.%20korespondensi.pdf https://repository.unair.ac.id/130002/ https://www.phcogj.com/article/2045 http://dx.doi.org/10.5530/pj.2023.15.89 |
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