Profile of cardiovascular disease risk in type 2 diabetes mellitus patients receiving statin therapy: A cross-sectional study

• Main Authors: Yasmin Karimah Ikhsan, -, Soebagijo Adi Soelistijo, Soebagijo, Johanes Nugroho Eko Putranto, -
• Format: Article PeerReviewed
• Language: English; Indonesian; English; English
• Published: Elsevier
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/130963/1/23.%20Artikel.pdf; https://repository.unair.ac.id/130963/2/23%20karil.pdf; https://repository.unair.ac.id/130963/3/23%20turnitin.pdf; https://repository.unair.ac.id/130963/4/23.%20korespondensi.pdf; https://repository.unair.ac.id/130963/; https://www.sciencedirect.com/science/article/pii/S2049080122001285; https://doi.org/10.1016/j.amsu.2022.103368
• Institution: Universitas Airlangga

Abstract Background Cardiovascular disease is still the number 1 cause of death globally. Meanwhile, type 2 diabetes mellitus (T2DM) is a risk factor for atherosclerosis vascular disease (ASCVD), so an assessment using Framingham Risk Score (FRS) is needed to predict the risk of ASCVD in the future. Objective Analyzing the risk factor of ASCVD using the Framingham Risk Score (FRS) in T2DM patients. Methods This study was conducted from July 2020 to July 2021, which the participants were measured for FRS including age, gender, current smoking, diabetes, blood pressure (systolic), high-density lipoprotein (HDL) cholesterol, total cholesterol (TC), and ASCVD risk score. The analysis employed multiple linear tests and ANOVA tests with p < 0.05. Results Several ASCVD risk factors in T2DM patients were found, including gender (t = 6.015; p < 0.001), age (t = 6.901; p < 0.001), HDL level (t = 2.287; p = 0.024), CT level (t = 5.273; p < 0.001), blood pressure (t = 5.850; p < 0.001), and current smoking (t = 2.638; p = 0.009). The results of analysis between ASCVD risk factor and level of ASCVD risk obtained a significant association (F = 36,642; p < 0.001). Conclusion Risk factors of ASCVD in T2DM patients such as gender, age, HDL level, CT level, blood pressure, and current smoking.