Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease
Chronic inflammation can have a considerable impact on the progression of glomerular and tubulointerstitial pathologies in chronic kidney disease (CKD). As an alternative to the early detection of inflammatory biomarkers that are most prominent in the progression of CKD, analyzing the relationship o...
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id-langga.1333312024-06-07T09:25:48Z https://repository.unair.ac.id/133331/ Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease Desty Indah Sari Puspa Wardhani, - YESSY PUSPITASARI, NIM011218156307 Satriyo Dwi Suryantoro, - RB37-56.5 Clinical pathology. Laboratory technique Chronic inflammation can have a considerable impact on the progression of glomerular and tubulointerstitial pathologies in chronic kidney disease (CKD). As an alternative to the early detection of inflammatory biomarkers that are most prominent in the progression of CKD, analyzing the relationship of monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and tumor necrosis factor-α (TNF-α) in CKD is the goal of this study. This cross-sectional study involved 65 CKD subjects, consisting of 5 stages of CKD in compliance with KDIGO standards. Estimated glomerular filtration rate (eGFR) was calculated utilizing the CKD epidemiology collaboration (CKD-EPI) creatinine formulation. MLR and NLR were calculated from the differential count hematology analyzer. TNF-α was examined using the sandwich ELISA method. Random-spot urine was used for the UACR examination. There were significant differences in MLR and TNF-α at various stages of CKD, whereas NLR exhibited no significant difference at different stages of CKD. There was a significant association in MLR, NLR, and the stages of CKD. However, TNF-α was not associated with the stages of CKD. Also, MLR and NLR were not correlated with TNF-α in CKD. Furthermore, MLR, NLR, and TNF-α had no significant relationship with urine albumin-creatinine ratio (UACR). In conclusion, MLR is better for assessing CKD progression than NLR and TNF-α. www.bsmiab.org 2024 Article PeerReviewed text en https://repository.unair.ac.id/133331/1/Association%20of%20monocyte-to-lymphocyte%20ratio%2C%20neutrophil-to-lymphocyte%20ratio.pdf text en https://repository.unair.ac.id/133331/2/T-Association%20of%20monocyte-to-lymphocyte%20ratio%2C%20neutrophil-to-lymphocyte%20ratio.pdf text en https://repository.unair.ac.id/133331/3/Association%20of%20monocyte-to-lymphocyte%20ratio%2C%20neutrophil-to-lymphocyte%20ratio.pdf Desty Indah Sari and Puspa Wardhani, - and YESSY PUSPITASARI, NIM011218156307 and Satriyo Dwi Suryantoro, - (2024) Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease. Journal of advanced biotechnology and experimental therapeutics, 7 (2). pp. 346-356. ISSN 2616-4760, https://doi.org/10.5455/jabet.2024.d29 |
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RB37-56.5 Clinical pathology. Laboratory technique Desty Indah Sari Puspa Wardhani, - YESSY PUSPITASARI, NIM011218156307 Satriyo Dwi Suryantoro, - Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
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Chronic inflammation can have a considerable impact on the progression of glomerular and tubulointerstitial pathologies in chronic kidney disease (CKD). As an alternative to the early detection of inflammatory biomarkers that are most prominent in the progression of CKD, analyzing the relationship of monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and tumor necrosis factor-α (TNF-α) in CKD is the goal of this study. This cross-sectional study involved 65 CKD subjects, consisting of 5 stages of CKD in compliance with KDIGO standards. Estimated glomerular filtration rate (eGFR) was calculated utilizing the CKD epidemiology collaboration (CKD-EPI) creatinine formulation. MLR and NLR were calculated from the differential count hematology analyzer. TNF-α was examined using the sandwich ELISA method. Random-spot urine was used for the UACR examination. There were significant differences in MLR and TNF-α at various stages of CKD, whereas NLR exhibited no significant difference at different stages of CKD. There was a significant association in MLR, NLR, and the stages of CKD. However, TNF-α was not associated with the stages of CKD. Also, MLR and NLR were not correlated with TNF-α in CKD. Furthermore, MLR, NLR, and TNF-α had no significant relationship with urine albumin-creatinine ratio (UACR). In conclusion, MLR is better for assessing CKD progression than NLR and TNF-α. |
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Article PeerReviewed |
author |
Desty Indah Sari Puspa Wardhani, - YESSY PUSPITASARI, NIM011218156307 Satriyo Dwi Suryantoro, - |
author_facet |
Desty Indah Sari Puspa Wardhani, - YESSY PUSPITASARI, NIM011218156307 Satriyo Dwi Suryantoro, - |
author_sort |
Desty Indah Sari |
title |
Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
title_short |
Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
title_full |
Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
title_fullStr |
Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
title_full_unstemmed |
Association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
title_sort |
association of monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and tumor necrosis factor-α in various stages of chronic kidney disease |
publisher |
www.bsmiab.org |
publishDate |
2024 |
url |
https://repository.unair.ac.id/133331/1/Association%20of%20monocyte-to-lymphocyte%20ratio%2C%20neutrophil-to-lymphocyte%20ratio.pdf https://repository.unair.ac.id/133331/2/T-Association%20of%20monocyte-to-lymphocyte%20ratio%2C%20neutrophil-to-lymphocyte%20ratio.pdf https://repository.unair.ac.id/133331/3/Association%20of%20monocyte-to-lymphocyte%20ratio%2C%20neutrophil-to-lymphocyte%20ratio.pdf https://repository.unair.ac.id/133331/ https://doi.org/10.5455/jabet.2024.d29 |
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