Risiko Penularan Virus Hepatitis C pada Anggota Keluarga Terpapar (Studi Epidemiologi Longitudinal Kelompok Kohort)
This study was performed to detect intra-familial transmission of HCV and to figure out the incidence of such transmission, to determine the risk of HCV transmission via intra-familial route on exposed family group compared to control group, and to ascertain the role of viremic level on the risk...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/133712/1/KKA%20KK%20Dis%20Dew%20r_ABSTRAK.pdf https://repository.unair.ac.id/133712/2/KKA%20KK%20Dis%20Dew%20r.pdf https://repository.unair.ac.id/133712/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | This study was performed to detect intra-familial transmission of HCV
and to figure out the incidence of such transmission, to determine the risk of
HCV transmission via intra-familial route on exposed family group compared
to control group, and to ascertain the role of viremic level on the risk of HCV
transmission on the exposed family.
The hypothesis of the study were (1) the presence of HCV-viraemic on
family members as a source of transmission (index case), consequently the
transmission of HCV will occur as shown by seroconversion of anti-HCV and
or HCV-RNA positive on family members of exposed group, (2) the risk of
HCV transmission on family members of exposed group is not different from
the same risk on unexposed group, and (3) the risk of intra-familial HCV
transmission is increased if the index cases showed higher viraemic level
than the lower one.
The initial samples were 524 family members which consist of 234
family members of exposed group and 290 family members of unexposed
group. At the end of this study, totally 1236 serum samples of family members
were examined, comprise of 556 family members of exposed group and 680
family members of unexposed group, selected by purposive sampling.
This study is longitudinal epidemiological study using cohort design.
Blood samples was drawn from both family members of exposed and
unexposed group at the beginning of the study, 6 months later, and on 236
samples at 12 months after the first sampling. Serologic markers of HBV and
HCV were examined on each samples. The presence of HCV-RNA were also
determined on each samples. To confirm the intrafamilial transmission of
HCV, the homology of HCV-RNA sequence of index case and infected case
were determined. At the end of the study, all respondents answered the
questionaire for determining the risk factors for HCV transmission. In this
study, longitudinal epidemilogical research was done to detect the incidence
of HCV transmission and a sophisticated biology molecular technique was
used to proved that the transmission occured intrafamilialy.
The data were analysed statistically by normality test (Kolmogorov
Smirnov Goodness of Fit test), homogeneity test, X2 test, Student's t test,
Relative risk, Mann Whitney test, and regression.
The results showed that the first and second hypothesis was accepted,
but concerning the third hypothesis, the null hypothesis could not be rejected.
On the first hypothesis, the incidence of HCV transmission on exposed family
members was found very low. On the second hypothesis, the result of this
study showed that the relative risk of intra-familial HCV transmission among
exposed family members was not different compared to the same risk on
unexposed family members. Whereas on the third hypothesis, the result of
this study showed no role of HCV viraemic level on intra-familial HCV
transmission. The results of this study support the epidemiology data of intrafamilial
HCV transmission which was very low, therefore the prevention of
HCV transmission especially directed to other routes of HCV transmission. |
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