Studi Hubungan Antara Nilai Lipofilitas (Σf) Turunan N-Benzoilsefaleksin Dan Aktivitas Antibakteri Terhadap Staphylococcus aureus ATCC 25923

• Main Author: Fifteen Aprila Fajrin, -
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian
• Published: 2004
• Subjects: RS Pharmacy and materia medica
• Online Access: https://repository.unair.ac.id/136208/1/050012273%20blm%20ada%20fulltext.pdf; https://repository.unair.ac.id/136208/; https://lib.unair.ac.id/
• Institution: Universitas Airlangga

This research was done to understand relationship between lipophilicity parameter of N-benzoilcephelexin derivatives with their antibacterial activity againts Staphylococcus aureus ATCC 25923. Lipophilicity parameter that was chosen is “sigma Rekker (Σf)” and antibacterial activity test was done with cylinder diffusion method. The relationship between lipophilicity parameters of N-benzoilcephelexin derivatives with their antibacterial activity againts Staphylococcus aureus ATCC 25923 was explained with linier regression. The result is Log DDH = -0,060 Σf + 1,306(r2 = 0,126; r = 0,354; F = 0,431; n= 5; rtable (α = 0,05; dF = 3) = 0,8783; Ftable (1;3;0,05)= 10,13). From the result, it could be concluded that lipophilicity parameters didn’t influence antibacterial activity N-benzoilcephalexin’s generation against Staphylococcus aureus ATCC 25923.