MEKANISME PENINGKATAN JUMLAH NEOVASKULAR PADA PENYEMBUHAN ULKUS TRAUMATIKUS SEBAGAI EFEK PEMBERIAN EKSTRAK BATANG PISANG MAULI (Musa acuminata) (Penelitian Eksperimental Pada Tikus Wistar)
Traumatic ulcer is an oral disorder that often happens and causes nutrition intake disorder. Mauli banana stem extract can accelerate mucosa wound healing. Nonetheless, the mechanism of increasing the number of neovasculars in wound healing process as an effect of mauli banana stem extract still...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/39651/1/ABSTRACT.pdf http://repository.unair.ac.id/39651/12/68.%2039651.pdf http://repository.unair.ac.id/39651/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Traumatic ulcer is an oral disorder that often happens and causes nutrition intake
disorder. Mauli banana stem extract can accelerate mucosa wound healing. Nonetheless, the
mechanism of increasing the number of neovasculars in wound healing process as an effect of
mauli banana stem extract still cannot be explained yet. The purpose of this study was to
explain the mechanism of the increase in the number of neovasculars through increased
expression of NFkβ, HIF-1α, and VEGF Hsp90α on healing traumatic ulcer as an effect of
giving the extract of mauli banana stems. The type of this study was a true experimental
research with factorial research design. The traumatic ulcer models were male Rattus
norvegicus Wistar strain. There were 40 samples divided into following groups; Negative
Control Group (K) given a gel, Group Treatment 1 (P1) given ethanol extract of mauli banana
stem 25%, Group Treatment 2 (P2) given ethanol extract of mauli banana stems 37, 5%,
treatment group 3 (P3) given ethanol extract of mauli banana stem 50%. It was done taking
the mucosal tissue to make preparation and immunohistochemical staining (IHC) and
Haematoxylin Eosin staining (HE). Data analysis was done with ANOVA. If the result was
not normal, the Kruskal Wallis test was conducted, then path analysis was performed. The
results showed the highest increase existed in the group of gel mauli banana stem extract
within concentration of 37.5%. The conclusions were that the effects of mauli banana stem
extract through the mechanism paths of NFkβ-VEGF- neovascular number, and the
mechanism path of HIF-1α-VEGF- neovascular number. Mauli banana extract increase the
number of neovasculars through immunomodulator effect. |
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