peradaan kadar zink serum pada pasien vitago dan kontrol di unit rawat jalan kesehatan kulit dan kelamin rsud Dr.Soetomo Surabaya

• Main Author: Dinar Witasari, NIM011180407
• Format: Theses and Dissertations NonPeerReviewed
• Published: 2016
• Subjects: R Medicine
• Online Access: http://repository.unair.ac.id/45416/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Background: Vitiligo is a common acquired depigmentary disease characterized by depigmented patches of the skin, hair and mucous membranes due to selective destruction of melanocytes. Zinc is one of the trace element that plays important role in pathogenesis of vitiligo. Previous research showed a controversial result in zinc level of vitiligo. Purpose: To compare serum zinc between vitiligo and control in Dermato-venereology outpatient clinic in dr. Soetomo general hospital Surabaya. Method: This is an analitic observational case control research, with 19 vitiligo patients in dermatovenereology outpatient clinic Dr.Soetomo hospital and 19 age-sex matched controls (non-vitiligo subjects) that qualify inclusion and exclusion criteria. Serum zinc level was measured in both groups using Atomic Absorbtion Spectrophotometer. Results: Mean serum zinc in vitiligo groups are 254,53 μg/dL and 109,53 μg/dL in control groups. This results is showed that mean serum zinc in vitiligo group significantly higher compared to control group (p<0,05). There was a statistically significant association between serum zinc level and progressivity of the lession as patient with active vitiligo lesion showed higher values of serum zinc. Stress is the most common predisposing factors (36%), meanwhile stress can also induce the increasing of serum zinc. Conclusions: Serum zinc in vitiligo patient is higher than control and showed association with course of the disease. Need further research to reveal the role of zink in vitiligo and the connection between the degree of stress and serum zinc.