IDENTIFIKASI GENOTIPE VIRUS HEPATITIS A DAN ANALISIS FAKTOR RISIKO KEJADIAN HEPATITIS A DI SMPN 29 DAN SMP UNESA 2 KOTA SURABAYA TAHUN 2016
Hepatitis A is still an important health problem worldwide. Indonesia also belongs to hepatitis A endemic area, due to the increased prevalence and distribution of hepatitis A cases since 2011. In Surabaya (capital of East Java Province), its incidence has increased since 2013 until 2015. The pur...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/49615/1/ABSTRAK.pdf http://repository.unair.ac.id/49615/13/TKT.06-16%20Wah%20i.pdf http://repository.unair.ac.id/49615/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Hepatitis A is still an important health problem worldwide. Indonesia also belongs
to hepatitis A endemic area, due to the increased prevalence and distribution of
hepatitis A cases since 2011. In Surabaya (capital of East Java Province), its incidence
has increased since 2013 until 2015. The purpose of this research was to identify
hepatitis A virus (HAV) genotype and to analyze its risk factors in two junior high
schools (SMPN 29 and SMP Unesa 2) in Surabaya in the recent outbreak in 2015. The
research method used a case-control design with 50 samples (33 cases and 17 controls).
Blood samples were collected to identify HAV infection (IgM anti-HAV) and HAV
genotype (PCR-sequencing). Some host and environment factors were examined by
interview and observation. Host risk factors were identified by using multivariate
analysis Of 50 samples, 33 had positive IgM anti-HAV and 5 had positive PCR
product. All HAV isolates (5) belonged to subgenotype IA. The significant host risk
factors included poor hand washing (p=0.0006, OR=8.704) and eating habit of
unhygienic food (p=0.023, OR=12.083). The students’ knowledge about hepatitis A
did not correlate with its incidence (p=0.531). Poor sanitation of clean water supplies
and lavatory, and also poor hygienic canteens were observed in the two schools. It can
be concluded that HAV-IA was predominant; some host factors and poor sanitation
contributed this outbreak. |
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