UJI AKTIVITAS ANTI KESEMUTAN DARI FRAKSI MINYAK KENCUR (Kaempferia galanga L.) DENGAN METODE INDUKSI PARATHRIN

• Main Author: RULI IHZA FAHRIZAL, 050911234
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2016
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/55647/1/FF.FT.%2017-16%20Fah%20u%20abstrak.pdf; http://repository.unair.ac.id/55647/2/FF.FT.%2017-16%20Fah%20u.pdf; http://repository.unair.ac.id/55647/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Paresthesia is a spontaneous or evoked abnormal sensation of tingling, burning, pricking, or numbness of a person’s skin with no apparent long-term physical effect. Paresthesia is a variety of neuropathic pain arises as a spontaneous and abnormal sensation. Type II synthethic pyrethroids, such as parathrin may affect the sodium channels of cutaneous nerve endings causing paresthesia at levels of exposure that do not provoke visible erythema. Ethyl p-methoxycinnamate (EPMC) is a major component of oil fraction from Kaempferia galanga L., which was reported to inhibit the enzymatic activity of COX-1 and COX-2, and has a higher anti-nociceptive activity than aspirin. This study was designed to investigate the effect of oil fraction from Kaempferia galanga L. on anti-paresthesia activity in mice. 100 μl parathrin solution was injected subcutaneously into mice after 20 minutes of administration of oil fraction suspension. After 30 minutes, Parathrininduced head shaking behavior in mice was recorded and counted using video camera for 10 minutes. Data was obtained and processed with oneway ANOVA statistical test, followed with LSD as a post hoc test. Results showed that mice which given samples test has less number of head shaking. The most effective dose of oil fraction is 16,09 mg/20 g body weight of mice. Keywords: Kaempferia galanga, ethyl p-methoxycinnamate, paresthesia, parathrin