UJI AKTIVITAS ANTI KESEMUTAN DARI FRAKSI MINYAK KENCUR (Kaempferia galanga L.) DENGAN METODE INDUKSI PARATHRIN
Paresthesia is a spontaneous or evoked abnormal sensation of tingling, burning, pricking, or numbness of a person’s skin with no apparent long-term physical effect. Paresthesia is a variety of neuropathic pain arises as a spontaneous and abnormal sensation. Type II synthethic pyrethroids, such a...
Saved in:
Main Author: | |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2016
|
Subjects: | |
Online Access: | http://repository.unair.ac.id/55647/1/FF.FT.%2017-16%20Fah%20u%20abstrak.pdf http://repository.unair.ac.id/55647/2/FF.FT.%2017-16%20Fah%20u.pdf http://repository.unair.ac.id/55647/ http://lib.unair.ac.id |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
Summary: | Paresthesia is a spontaneous or evoked abnormal sensation of
tingling, burning, pricking, or numbness of a person’s skin with no apparent
long-term physical effect. Paresthesia is a variety of neuropathic pain arises
as a spontaneous and abnormal sensation. Type II synthethic pyrethroids,
such as parathrin may affect the sodium channels of cutaneous nerve
endings causing paresthesia at levels of exposure that do not provoke visible
erythema.
Ethyl p-methoxycinnamate (EPMC) is a major component of oil
fraction from Kaempferia galanga L., which was reported to inhibit the
enzymatic activity of COX-1 and COX-2, and has a higher anti-nociceptive
activity than aspirin.
This study was designed to investigate the effect of oil fraction
from Kaempferia galanga L. on anti-paresthesia activity in mice. 100 μl
parathrin solution was injected subcutaneously into mice after 20 minutes of
administration of oil fraction suspension. After 30 minutes, Parathrininduced
head shaking behavior in mice was recorded and counted using
video camera for 10 minutes. Data was obtained and processed with oneway
ANOVA statistical test, followed with LSD as a post hoc test. Results
showed that mice which given samples test has less number of head
shaking. The most effective dose of oil fraction is 16,09 mg/20 g body
weight of mice.
Keywords: Kaempferia galanga, ethyl p-methoxycinnamate, paresthesia,
parathrin |
---|