UJI EFEK SEDATIF EKSTRAK DAUN Phyllanthus acidus L. DENGAN EKSTRAKSI BERTINGKAT TERHADAP MENCIT JANTAN GALUR Balb/C
Difficulty falling asleep or insomnia is a lack of quality of sleep, caused by hard to fall asleep, waking up at the middle of night and hard to sleep again, earlier to wake up in the morning, and unsound sleep. Diazepam, a benzodiazepine derivatives, is one of the medicine used for the treatmen...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/55651/1/FF.FT.%2020-16%20Ben%20u%20abstrak.pdf http://repository.unair.ac.id/55651/2/FF.FT.%2020-16%20Ben%20u.pdf http://repository.unair.ac.id/55651/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | Difficulty falling asleep or insomnia is a lack of quality of sleep,
caused by hard to fall asleep, waking up at the middle of night and hard to
sleep again, earlier to wake up in the morning, and unsound sleep.
Diazepam, a benzodiazepine derivatives, is one of the medicine used for the
treatment. This medicine is often misused by patients so that the resulting
dependency. The search for a new alternative medicine from natural
materials which has sedative effect is necessary to overcome insomnia. One
of plants that has sedative effect is Phyllanthus acidus L. from
Euphorbiaceae genus This study was aimed to evaluate the in vitro
antimalarial activity of n-hexane extract, chloroform extract, and 96%
ethanolic extract of Phyllanthus acidus L. leaves. The n-hexane,
chloroform, and 96% ethanolic extracts were obtained by multiple
maceration of powdered dried Phyllanthus acidus L. According to the result
of the study, n-hexane extract has sedative effect. The dosage is 500mg/kg
for every extract while the positive control is 10mg. Result of the analysis
of Mann Whitney shows that n-hexane extract gives insignificant difference
(p=0.42). Result of the study shows that n-hexane and positive control are
not different and both have sedative effect. Obstacle percentage of n-hexane
extract that over 50% is considered to have effective concentration to give
sedative effect.
Keywords: Phyllanthus acidus L., sedative, rotarod, Diazepam |
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