TOKSISITAS AKUT TABLET FRAKSI ETIL ASETAT-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR JANTAN
This present study was aimed to determine LD50, to establish the safety of ethyl acetate-96 bitter herbs/sambiloto (Androgarphis paniculata Nees.) fraction tablet by acute oral toxicity study in male wistar rats and to know the effects on liver and kidney of rats. Rats were administered the table...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/55661/1/FF.FT.%2024-16%20Naj%20t%20abstrak.pdf http://repository.unair.ac.id/55661/13/FF.FT.%2024-16%20Naj%20t-min.pdf http://repository.unair.ac.id/55661/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | This present study was aimed to determine LD50, to establish the safety of
ethyl acetate-96 bitter herbs/sambiloto (Androgarphis paniculata Nees.)
fraction tablet by acute oral toxicity study in male wistar rats and to know
the effects on liver and kidney of rats. Rats were administered the tablet
per-oral in single dose using fixed dose method: 5 mg/kg of body weight,
50 mg/kg of body weight, 300 mg/kg of body weight dan 2000 mg/kg of
body weight. All the animals were individually studied for mortality,
behavioral pattern or toxicity symptomps and body weight changes for 14
days. No mortality and no significance different changes of body weight
were found, and no toxicity symptomps at the highest dose 2000 mg/kg
body weight which reveal the safety of these tablets in the doses up to
2000 mg/kg weight. Further, ethyl acetate-96 bitter herbs (Andrographis
paniculata Nees.) fraction tablet did not cause the histopathological
changes both liver and kidney of rats. overall, the results suggest that the
oral administration of these tablets did not produce any significant toxic
effect in rats in acute toxicity study.
Keyword: sambiloto, Andrographis paniculata, EA fraction, acute
toxicity, liver histopathology, kidney histopathology |
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