SINTESIS SENYAWA ASAM 2-(BENZOILOKSI)-5-METOKSI BENZOAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus)
Synthesis of 2-(benzoyloxy)-5-methoxybenzoate and Analgesic Activity Test in Mice (Mus musculus) Ade Fili Sophia In an effort to enhance the analgesic activity of acetosal, the structural modification of acetosal was performed by synthesizing derivative 2- (benzoyloxy) -5-methoxy benzoate. The...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian Indonesian |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/56194/1/FF.%20KF.%2026-16%20Sop%20s%20abstrak.pdf http://repository.unair.ac.id/56194/2/FF.%20KF.%2026-16%20Sop%20s%20lampiran.pdf http://repository.unair.ac.id/56194/3/FF.%20KF.%2026-16%20Sop%20s%20bab.pdf http://repository.unair.ac.id/56194/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian Indonesian |
| Summary: | Synthesis of 2-(benzoyloxy)-5-methoxybenzoate and Analgesic Activity
Test in Mice (Mus musculus)
Ade Fili Sophia
In an effort to enhance the analgesic activity of acetosal, the
structural modification of acetosal was performed by synthesizing
derivative 2- (benzoyloxy) -5-methoxy benzoate. The compound 2-
(benzoyloxy) -5-methoxy benzoate is salicylic acid derivative was
synthesized and tested using a writhing test in mice (Mus musculus).
Synthesis reaction is a Schotten-Baumann reaction using reagent 5-
methoxy salicylic acid and benzoyl chloride in THF as a solvent. For the
alkaline condition is used pyridine which also serves as a catalyst and
neutralize HCl. The result was obtained by the synthesis is 52.4% in the
form of a solid white powder that was insoluble in water. Its purity was
tested by melting point test and Thin Layer Chromatography (TLC). The
structure was confirmed by UV-Visible spectrophotometry, infrared
spectrophotometry and 1H-NMR spectrometry. The result of analgesic
activity was showed that the compound 2- (benzoyloxy) -5-methoxy
benzoate had lower ED50 than acetosal. ED50 of 2- (benzoyloxy) -5-methoxy
benzoate is 49.56 mg/kg body-weight and ED50 acetosal is 80.28 mg/kg
body-weight. It concluded that 2- (benzoyloxy) -5-methoxy benzoate have
higher analgesic activity than acetosal.
Keyword: synthesis, 2- (benzoyloxy) -5-methoxy benzoate, analgesic
activity |
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