In Vitro Antimalarial Activity Screening of Several Indonesian Plants Using HRP2 Assay
Objective: Antimalarial drug resistance has emerged as one of the greatest challenges facing malaria disease control today. The spread of drug resistance and the limitation number of effective drugs for treatment indicated important to find a new antimalarial drugs. The aim of this study was to d...
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| Main Authors: | , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian English English English |
| Published: |
Innovare Academic Sciences
2014
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/56542/1/9306.pdf https://repository.unair.ac.id/56542/2/5%20Penilaian%20Reviewer.pdf https://repository.unair.ac.id/56542/12/C18-ARTIKEL.pdf https://repository.unair.ac.id/56542/13/C18-PEER%20REVIEW.pdf https://repository.unair.ac.id/56542/14/C18-SIMILARITY.pdf https://repository.unair.ac.id/56542/ http://www.ijppsjournal.com/Vol6Issue6/9306.pdf |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English English English |
| Summary: | Objective: Antimalarial drug resistance has emerged as one of the greatest challenges facing malaria disease control today. The spread of drug
resistance and the limitation number of effective drugs for treatment indicated important to find a new antimalarial drugs. The aim of this study
was to determine antimalarial activity several Indonesia plants.
Methods: Twenty leaves and stems of plants which were obtained from exploration from Alas Purwo National Park, East Java, Indonesia, were
extracted with ethanol 80% by “maceration technique assisted ultrasonic”. These 20 extracts were tested for in vitro antimalarial activity againt P.
falciparum 3D7 strain (chloroquine-sensitive), using the histidine-rich protein II (HRP2) assay.
Results: Two leaves extracts were active as an antimalarial, Garuga floribunda leaves (GFL) and Alectryon serratus leaves (ASL) with the value of
IC50 <14.8µg/mL and between 15.5-30.9 µg/mL respectively. These extracts contained rich chemical substances that considered for the antimalarial activity, such as terpenoids, polyphenol, flavonoids, and anthraquinone.
Conclusion: GFL and ASL were active as an antimalarial and potential to be developed as a new antimalarial drug. |
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