Effect Of Fursultiamine Supplementation On Left Ventricular Ejection Fraction (LVEF) In Grade III-IV Heart Failure Patients.

• Main Authors: Ririn IP, Suharjono, M. Aminuddin
• Format: Article PeerReviewed
• Language: English; Indonesian
• Published: Fakultas Kedokteran Unair 2015
• Subjects: R Medicine; RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/56691/1/download-fullpapers-fmia9b02ce845full.pdf; http://repository.unair.ac.id/56691/2/12.%20Bukti%20C-12%20Penilaian%20Karya%20Ilmiah.pdf; http://repository.unair.ac.id/56691/; http://journal.unair.ac.id/effect-of-fursultiamine-supplementation-on-left-ventricular-ejection-fraction-(lvef)-in-grade-iii-%E2%80%93-iv-heart-failure-patients-article-9477-media-3-category-.html
• Institution: Universitas Airlangga

Heart failure is a growing problem and affecting more than 20 millions people around the world. Pharmacology therapy that has been use for heart failure management are combination of diuretic, ACE-I, ARB, digitalis, beta blocker and MRA. The purpose of that therapy is to improve haemodynamic function, neurohormonal modulation, and cardiac electrophysiology. But they aren’t able to fulfill the metabolic demand of the failing heart. Micronutrient supplementation along with standard combination therapy will create synergistic effect not only on haemodynamic function but also on cardiac energy metabolism. Thiamin (B1 vitamin) is one of micronutrients that be able to work on cardiac energy metabolism, where as fursultiamine is thiamin derifative which has better cell penetration than thiamin it self. The purpose of this reasearch is to evaluate the effect after fursultiamine supplementation on cardiac function measured by the improvement on left ventricular ejection fraction (LVEF). The result of this research shows that fursultiamine supplementation along with standard combination therapy can give higher LVEF improvement than the patient that receive standard combination therapy alone. (FMI 2015;51:101-105)