CRP and IGA Levels in Wasting Children Under Five Based on Zinc and Retinol Level

• Main Authors: Merryana, Adriani, Bambang, Wirjatmadi, Virginia, Utermohlen, Kuntoro
• Format: Conference or Workshop Item PeerReviewed
• Language: English; Indonesian
• Published: International Conference on Nutrition and Food Sciences 2012
• Subjects: TX341-641 Nutrition. Foods and food supply
• Online Access: http://repository.unair.ac.id/56975/1/20%20.pdf; http://repository.unair.ac.id/56975/2/Peer%20Riview%2020.pdf; http://repository.unair.ac.id/56975/; http://www.ipcbee.com/list-62-1.html
• Institution: Universitas Airlangga

The effect of zinc deficiency may have play role on immune response that takes place during the critical growth period. Disorder of immune system may lead to the increased risk of infectious diseases.Immunoglobulin A (IgA) has a function as the first time barrier againts microorganisms and cell proliferation within immune system, which also highly influenzed by zinc. In children with malnutrition, including zinc, disorder, the production of secretory Ig A within their digestive system is also disturbed. The objective of this study was to analyze the difference of CRP and IgA levels on normal zinc levels and low zinc levels in wasted children underfives in Peneleh Puclic Health Center Surabaya City. Crossectional comparative design was done in 28 wasting children. Underfive children were randomized to observed CRP and IgA level. At the end of the study there were no significant differences in serum CRP level (p > 0.05)between children with low serum zinc levels and normal zinc levels (P=1.000). Children with higher serum zinc levels had higher blood levels of IgA (p=0.005). There were significant differences in IgA level (p =0,001) between children with normal zinc level and low zinc level. The result suggested that normal zinc levels may play role to perform antibody (IgA) for wasted underfive children to protect infection diseases than low zinc levels in wasted children under five.