KARAKTERISTIK FISIK DAN KELARUTAN SISTEM KOMPLEKS QUERCETIN - HYDROGENATED SOYBEAN PHOSPHATIDYLCHOLINE (HSPC)

• Main Author: FIRMANSYAH RACHMAN, 051211133048
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2016
• Subjects: RM300-666 Drugs and their actions; RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/57446/1/FF.%20F.%2053-16%20Rac%20k%20abstrak.pdf; http://repository.unair.ac.id/57446/2/FF.%20F.%2053-16%20Rac%20k.pdf; http://repository.unair.ac.id/57446/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Quercetin in the pharmaceutical application is still limited due to poor absorption and included in the BCS class II (Kakran, et. al., 2011). Therefore, in this study will be made complex with phospholipids Hydrogenated Soybean Phosphatidylcholine (HSPC) which can increase the solubility of Quercetin. The ability of phospholipid complex stable and more bioavailable with low interfacial tension between the liquid GIT system. This is very effective in improving the solubility, absorption, and the permeation of the active ingredient. The purpose of this study was to determine the physical characteristics and solubility of Quercetin-HSPC Complex with two types of ratio, 1:1 and 2:1. Specific characteristics include morphology, thermal properties, X-Ray diffraction pattern, chemical bond with the FTIR test, and solubility test. Quercetin-HSPC Complex was made by solvent evaporation method. The results of the physical characteristics of morphology showed no crystals that are identical to the single Quercetin in Quercetin-HSPC 1:1 and 2:1 complex. In the thermal analysis and X-Ray diffraction the crystal of Quercetin was not found in the complex, so that the molecule Quercetin has been distributed homogeneously in the system. In a chemical bonds test also showed a shift wave number of the C = O group in the complex. Solubility test results showed an increase in the solubility of the Quercetin-HSPC complex of 2:1 ratio. While on Quercetin-HSPC complex 1:1 had no increase and the results of statistical analysis of data by ANOVA showed no significant difference between Quercetin, Quercetin-HSPC complex 1:1 ratio and 2:1 ratio. Keyword : Phospholipid Complex, Quercetin, Hydrogenated Soybean Phosphatidylcholine, HSPC, Quercetin-HSPC Complex